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Neurofibromatosen: ein Überblick

Neurofibromatoses: a review

  • Leitthema
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Zusammenfassung

Die Neurofibromatosen (NF) zählen zur Gruppe der Phakomatosen. Sie werden definiert als Erkrankungen mit pathologisch veränderten Hüllzellen des peripheren Nervensystems. Die beiden wichtigsten Formen, NF Typ I (NF1) und NF Typ II (NF2) sind autosomal vererbbare Krankheiten mit einer Prädisposition zur Entwicklung von Neubildungen. Der vorliegende Beitrag beschreibt beide Entitäten und gibt eine kurze Übersicht über die Differenzialdiagnose der Neurofibromatosen sowie die speziellen Aspekte der mund-, kiefer- und gesichtschirurgischen Therapieoptionen.

Abstract

Neurofibromatoses (NF) belong to the group of phakomatoses and are defined as diseases with pathologically altered nerve sheath cells of the peripheral nervous system. The two most important forms NF type 1 (NF1) and NF type 2 (NF2) are autosomal inherited diseases with a predisposition to develop neoplasms. The article gives a short review about the diagnosis of neurofibromatoses with special reference to the therapeutic options provided by oral and maxillofacial surgeons.

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  1. Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinstr. 52, 20246, Hamburg, Deutschland

    R.E. Friedrich

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Friedrich, R. Neurofibromatosen: ein Überblick. MKG-Chirurg 6, 23–35 (2013). https://doi.org/10.1007/s12285-012-0331-x

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