Abstract
Ten stage I/II breast cancer patients with one or two suspicious lymph nodes (LNs) detected on ultrasonography underwent sentinel LN biopsy (SLNB) after the introduction of Twirl® breast markers into each suspicious LN revealed that each Twirl®-marked LN was SLN and was likely the first SLN. Three patients had less than three SLN metastases and were candidates for sparing completion axillary lymph node dissection (cALND). Indeed, of them, one underwent breast-conserving surgery without cALND and the other two underwent total mastectomy with cALND. These results suggest that, as all suspicious LNs are SLNs, patients can be treated with SLNB alone if they fulfill the ACOSOG Z-0011 criteria, despite suspicious LNs yielding positive results on preoperative fine-needle aspiration cytology.
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Acknowledgements
The authors are grateful to Akimitsu Miyake of the Data Coordinating Center at Osaka University Hospital for statistical advice in the peer review process and Hiroki Shoji of the Laboratory for Clinical Investigation at Osaka University Hospital for performing the OSNA diagnostic assay.
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The authors received no financial support for the research, authorship, and/or publication of this article.
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All authors contributed to the study conception and design. Data collection and analysis were performed by TM, MS, TT, NK, YN and SN. The first draft of the manuscript was written by TM and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Naoi Y. has received research funding not related to this study from Sysmex as well as holds joint patents not related to this study with Sysmex; Shimazu K. has received honoraria not related to this study from Sysmex; Noguchi S. is an advisory for and has received honoraria and research funding not related to this study from Sysmex as well as holds joint patents not related to this study with Sysmex; The other authors do not declare any conflict of interest related to this study.
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Miyake, T., Shimoda, M., Tanei, T. et al. Sentinel lymph node biopsy after introducing Twirl® breast markers into suspicious lymph nodes in breast cancer patients. Breast Cancer 28, 772–775 (2021). https://doi.org/10.1007/s12282-020-01195-9
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DOI: https://doi.org/10.1007/s12282-020-01195-9