Abstract
Background
Breast cancer is one of the most prevalent cancers in women. Oncotype Dx is a multi-gene assay frequently used to predict the recurrence risk for estrogen receptor-positive early breast cancer, with values < 18 considered low risk; ≥ 18 and ≤ 30, intermediate risk; and > 30, high risk. Patients at a high risk for recurrence are more likely to benefit from chemotherapy treatment.
Methods
In this study, clinicopathological parameters for 37 cases of early breast cancer with available Oncotype Dx results were used to estimate the recurrence score using the three new Magee equations. Correlation studies with Oncotype Dx results were performed. Applying the same cutoff points as Oncotype Dx, patients were categorized into low-, intermediate- and high-risk groups according to their estimated recurrence scores.
Results
Pearson correlation coefficient (R) values between estimated and actual recurrence score were 0.73, 0.66, and 0.70 for Magee equations 1, 2 and 3, respectively. The concordance values between actual and estimated recurrence scores were 57.6%, 52.9%, and 57.6% for Magee equations 1, 2 and 3, respectively. Using standard pathologic measures and immunohistochemistry scores in these three linear Magee equations, most low and high recurrence risk cases can be predicted with a strong positive correlation coefficient, high concordance and negligible two-step discordance.
Conclusions
Magee equations are user-friendly and can be used to predict the recurrence score in early breast cancer cases.
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Acknowledgements
This research was supported by King Hussein Cancer Center. We would like to thank our colleague from the statistics section Ms. Dalia Al-Rimawi who provided her expertise that greatly assisted the research. We would like to thank Springer Nature Author Services for professional English editing of this manuscript.
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Sughayer, M., Alaaraj, R. & Alsughayer, A. Applying new Magee equations for predicting the Oncotype Dx recurrence score. Breast Cancer 25, 597–604 (2018). https://doi.org/10.1007/s12282-018-0860-x
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DOI: https://doi.org/10.1007/s12282-018-0860-x