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Breast Cancer

, Volume 25, Issue 4, pp 402–406 | Cite as

Clinical development of CDK4/6 inhibitor for breast cancer

  • Hiroji Iwata
Special Feature Resistance to hormonal therapy

Abstract

Endocrine therapy is the mainstay of treatment for patients with estrogen receptor positive (ER+)/HER2-negative (HER2−) metastatic breast cancer (MBC). Many clinicians consider the sequential endocrine therapy is gold standard strategy because of better outcome and the maintenance of a better quality of life (QOL) for MBC patients. However, clinical practice shall be changed according to development of CDK4/6 inhibitor in current. CDK4/6 is key kinase which promote the cell cycle, and especially the expression of cyclin D1 and the activation of CDK4/6 to drive breast cancer proliferation. Currently positive data of several clinical trials using three CDK4/6 inhibitors (palbocilcib, ribociclib, abemaciclib) were published and primary endpoint were met in all phase III studies. Therefore, practice change of endocrine therapy has been achieved in ER positive MBC. This review will present clinical trial data, including both the efficacy and safety of CDK4/6 inhibitors for MBC, and describe the designs of the mainly ongoing clinical trials examining CDK4/6 inhibitors for the treatment of MBC and EBC.

Keywords

Breast Cancer CDK inhibitors Palbociclib Ribocciclib Abemaciclib 

Notes

Compliance with ethical standards

Conflict of interest

I have conflict of interest about this paper to declare as follow Honoraria: Pfizer. Research Fund (registration study fee): Pfizer, Novartis, Lilly.

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Copyright information

© The Japanese Breast Cancer Society 2018

Authors and Affiliations

  1. 1.Department of Breast OncologyAichi Cancer Center HospitalNagoyaJapan

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