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Effect of the chest wall on the measurement of hemoglobin concentrations by near-infrared time-resolved spectroscopy in normal breast and cancer

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Abstract

Background

Optical imaging and spectroscopy using near-infrared light have great potential in the assessment of tumor vasculature. We previously measured hemoglobin concentrations in breast cancer using a near-infrared time-resolved spectroscopy system. The purpose of the present study was to evaluate the effect of the chest wall on the measurement of hemoglobin concentrations in normal breast tissue and cancer.

Methods

We measured total hemoglobin (tHb) concentration in both cancer and contralateral normal breast using a near-infrared time-resolved spectroscopy system in 24 female patients with breast cancer. Patients were divided into two groups based on menopausal state. The skin-to-chest wall distance was determined using ultrasound images obtained with an ultrasound probe attached to the spectroscopy probe.

Results

The apparent tHb concentration of normal breast increased when the skin-to-chest wall distance was less than 20 mm. The tHb concentration in pre-menopausal patients was higher than that in post-menopausal patients. Although the concentration of tHb in cancer tissue was statistically higher than that in normal breast, the contralateral normal breast showed higher tHb concentration than cancer in 9 of 46 datasets. When the curves of tHb concentrations as a function of the skin-to-chest wall distance in normal breast were applied for pre- and post-menopausal patients separately, all the cancer lesions plotted above the curves.

Conclusions

The skin-to-chest wall distance affected the measurement of tHb concentration of breast tissue by near-infrared time-resolved spectroscopy. The tHb concentration of breast cancer tissue was more precisely evaluated by considering the skin-to-chest wall distance.

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Numbers 25861082 and 26282144.

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Authors and Affiliations

  1. Department of Diagnostic Radiology and Nuclear Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Nobuko Yoshizawa, Hatsuko Nasu & Harumi Sakahara

  2. Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakitaku, Hamamatsu, Shizuoka, 434-8601, Japan

    Yukio Ueda, Etsuko Ohmae, Kenji Yoshimoto & Yutaka Yamashita

  3. Department of Breast Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Hiroyuki Ogura

  4. Department of Radiology, Hamamatsu University Hospital, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Yasuo Takehara

Authors
  1. Nobuko Yoshizawa
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  2. Yukio Ueda
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  3. Hatsuko Nasu
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  4. Hiroyuki Ogura
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  6. Kenji Yoshimoto
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  7. Yasuo Takehara
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  8. Yutaka Yamashita
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  9. Harumi Sakahara
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Correspondence to Nobuko Yoshizawa.

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Yoshizawa, N., Ueda, Y., Nasu, H. et al. Effect of the chest wall on the measurement of hemoglobin concentrations by near-infrared time-resolved spectroscopy in normal breast and cancer. Breast Cancer 23, 844–850 (2016). https://doi.org/10.1007/s12282-015-0650-7

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  • DOI: https://doi.org/10.1007/s12282-015-0650-7

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