Abstract
Background
To review the initial results of the implementation of a risk assessment program in our outpatient community-based breast-imaging practice.
Methods
From May 1, 2011 through November 4, 2013 a total of 96,389 patients presented to our facility. Each patient was required to complete a health history form. 24,850 (25.7 %) were flagged through our radiology information system (RIS) as potentially being at increased risk for breast cancer per responses on the health history form. Patient flagging was based on a system we developed. Letters were generated informing flagged patients and her physician that the patient could be a candidate for further breast cancer risk assessment. Genetic testing performed was primarily for BRCA1/BRCA2; testing for other mutations was offered based on personal and family history of the patient.
Results
1,088 genetic counseling appointments occurred during the time frame from the 24,850 patients flagged, leading to 887 genetic tests performed. Forty-three mutations were detected: 21 BRCA1, 19 BRCA2, 1 MLH1, 1 MSH6 and 1 CHEK2. There were 717 negative tests, 20 variants of unknown significance; the remaining cases were cancelled. 464 high-risk MRIs were performed after the patient was referred from the program, from which 52 biopsies were performed due to a finding on MRI revealing 14 malignancies.
Conclusions
In our experience after implementation of a risk assessment program, 24,850 potential at-risk patients have been flagged, revealing 40 BRCA 1 or 2 mutations. Screening with breast MRI provided to at-risk patients revealed 14 cancers diagnosed that may have otherwise been undetected.
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Acknowledgments
The authors would like to thank Jessica Salamone, ScM, CGC, and Kristie Smith, MS, CGC, for their invaluable assistance with the preparation of this manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
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Destounis, S., Arieno, A. & Morgan, R. Implementation of a risk assessment program in a breast-imaging community practice. Breast Cancer 23, 273–278 (2016). https://doi.org/10.1007/s12282-014-0569-4
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DOI: https://doi.org/10.1007/s12282-014-0569-4