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Diagnosis, Burden and Mortality of Pneumocystis jirovecii Pneumonia in Venezuela

  • Clinical Mycology Lab Issues (S Cordoba, Section Editor)
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Abstract

Purpose of the Review

The aim of this work is to contribute to the knowledge of diagnosis, burden, and mortality of pneumocystosis or Pneumocystis jirovecii pneumonia (PCP) in Venezuela.

Recent Findings

Historically, PCP diagnosis has been clinical and histopathological, but diagnosis based on PCP clinical suspicion, without confirmation of laboratory detection of P. jirovecii, causes a significant negative impact on both morbidity and mortality of this disease. Risk estimation for PCP and mortality rates according to official records contrasts with the scarce epidemiological data and makes more difficult to have a real view of the impact of this disease in our country.

Summary

This review summarizes three fundamental aspects: the meaning and usefulness of direct immunofluorescence assay (DIF) and nested PCR (nPCR) for PCP diagnosis in a developing country, risk estimation for PCP based on available national publications, and official mortality rates.

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Acknowledgments

We want to thank to all members of IBEROPNEUMOCYSTIS, especially Olga Matos (Universidade NOVA de Lisboa) and Carmen de La Horra and Vicente Friaza (Instituto de Biomedicina de Sevilla, España), for their support and friendship. We also want to thank David Denning and Ana Alastruey-Izquierdo for their support and Lieska Rodríguez, Manager of Diagnosis and Epidemiological Surveillance of Rafael Rangel National Institute of Hygiene.

Venezuelan Group for the Study of Pneumocystosis

María Mercedes Panizo, Giuseppe Ferrara, and Nataly García (were part of the group of the Instituto Nacional de Higiene Rafael Rangel until May 2019); Vera Reviakina and Maribel Dolande (currently retired professionals from the Instituto Nacional de Higiene Rafael Rangel); Víctor Alarcón (Instituto Nacional de Higiene Rafael Rangel); Xiomara Moreno and Ana María Cáceres (Instituto Médico La Floresta); Trina Navas (Hospital General del Oeste Dr. José Gregorio Hernández); Enrique Calderon is the coordinator of the Iberoamerican Pneumocystis Network (IBEROPNEUMOCYSTIS). Maria Mercedes Panizo was the leader of the Venezuelan group.

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María Mercedes Panizo, Giuseppe Ferrara, Nataly García, Xiomara Moreno, Trina Navas, and Enrique Calderón declare no conflicts of interest relevant to this manuscript.

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Panizo, M.M., Ferrara, G., García, N. et al. Diagnosis, Burden and Mortality of Pneumocystis jirovecii Pneumonia in Venezuela. Curr Fungal Infect Rep 14, 29–39 (2020). https://doi.org/10.1007/s12281-020-00377-4

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