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Current Fungal Infection Reports

, Volume 13, Issue 2, pp 59–66 | Cite as

Non-Aspergillus Fungal Infections in Chronic Granulomatous Disease

  • Romain Guery
  • Benoît Pilmis
  • Bertrand Dunogue
  • Stéphane Blanche
  • Olivier Lortholary
  • Fanny LanternierEmail author
Pediatric Fungal Infections (D Corzo-Leon, Section Editor)
  • 14 Downloads
Part of the following topical collections:
  1. Topical Collection on Pediatric Fungal Infections

Abstract

Purpose of Review

Management of Aspergillus infection in chronic granulomatous disease (CGD) patients remains a challenge even in new azoles era. However, epidemiology, diagnosis, and management of non-Aspergillus fungal infection (NAFI) in CGD setting are poorly described.

Recent Findings

NAFI appears to be rare in CGD patients and receiving antifungal prophylaxis. Clinical presentation is not specific of fungal species and patients often suffer from mild disease with prolonged course. While candidiasis and mucormycosis are also common in other immunocompromised population, infections caused by Phellinus tropicalis, Trichosporon inkin, and Rasamsonia argillacea have a unique predilection for CGD patients. Improved fungal identification with molecular methods allows description of new fungal species.

Summary

The available data for NAFI during CGD are limited and based on case reports and small series. Invasive tissue biopsies and advanced molecular methods are often required for diagnosis and guiding antifungal strategy in addition to a close collaboration between clinician, pathologist, and mycologist.

Keywords

Invasive fungal disease Chronic granulomatous diseases Trichosporon inkin Phellinus tropicalis Rasamsonia argillacea Breakthrough infections Pediatric patients 

Notes

Acknowledgments

We thank Marie Desnos-Ollivier for her helpful comments.

Compliance with Ethical Standards

Conflict of Interest

Romain Guery reports participating in CME with support from Gilead outside the submitted work. Benoît Pilmis reports personal fees from MSD outside the submitted work. Fanny Lanternier reports personal fees from Gilead outside the submitted work. Bertrand Dunogue, Stéphane Blanche, and Olivier Lortholary declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Romain Guery
    • 1
  • Benoît Pilmis
    • 1
    • 2
  • Bertrand Dunogue
    • 3
  • Stéphane Blanche
    • 4
  • Olivier Lortholary
    • 1
    • 5
  • Fanny Lanternier
    • 1
    • 5
    Email author
  1. 1.Sorbonne Paris Cité, Infectious Diseases Unit, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Imagine InstituteParis Descartes UniversityParisFrance
  2. 2.Antimicrobial stewardship team, Microbiology UnitGroupe Hospitalier Paris Saint JosephParisFrance
  3. 3.Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital CochinAssistance Publique-Hôpitaux de Paris (AP-HP)ParisFrance
  4. 4.Pediatric Immuno-Haematology and Rheumatology Unit, Assistance Publique-Hôpitaux de Paris (AP-HP)Necker Enfants Malades University HospitalParisFrance
  5. 5.Institut Pasteur, CNRS, Centre National de Référence Mycoses Invasives et AntifongiquesUnité de Mycologie Moléculaire, UMR 2000ParisFrance

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