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Pathogenesis of Coccidioidomycosis

Abstract

Coccidioidomycosis is a systemic fungal infection endemic to the American Southwest, caused by Coccidioides immitis and Coccidioides posadasii. The infection has a wide variety of clinical manifestations in humans, from asymptomatic infection to severe disease. Infection occurs through inhalation of fungal spores, leading to primary pulmonary infection and occasionally to hematogenous dissemination to other sites. Both fungal and host factors contribute to pathogenesis of this infection. Cellular and innate immune responses are involved in the protective response in both humans and mice. This review summarizes recent research on microbial and host factors involved in the pathogenesis of coccidioidomycosis.

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Conflict of Interest

Neil M. Ampel and Susan E. Hoover declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Susan E. Hoover.

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This article is part of the Topical Collection on Fungal Genomics and Pathogenesis

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Ampel, N.M., Hoover, S.E. Pathogenesis of Coccidioidomycosis. Curr Fungal Infect Rep 9, 253–258 (2015). https://doi.org/10.1007/s12281-015-0242-1

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Keywords

  • Coccidioides
  • Coccidioidomycosis
  • Innate and adaptive immunity
  • Virulence factors
  • Systemic fungal infection
  • Fungal infection
  • Coccidioidomycosis pathogenesis
  • Fungal pathogenesis