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Current Fungal Infection Reports

, Volume 9, Issue 4, pp 253–258 | Cite as

Pathogenesis of Coccidioidomycosis

  • Neil M. Ampel
  • Susan E. HooverEmail author
Fungal Genomics and Pathogenesis (S Shoham, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Fungal Genomics and Pathogenesis

Abstract

Coccidioidomycosis is a systemic fungal infection endemic to the American Southwest, caused by Coccidioides immitis and Coccidioides posadasii. The infection has a wide variety of clinical manifestations in humans, from asymptomatic infection to severe disease. Infection occurs through inhalation of fungal spores, leading to primary pulmonary infection and occasionally to hematogenous dissemination to other sites. Both fungal and host factors contribute to pathogenesis of this infection. Cellular and innate immune responses are involved in the protective response in both humans and mice. This review summarizes recent research on microbial and host factors involved in the pathogenesis of coccidioidomycosis.

Keywords

Coccidioides Coccidioidomycosis Innate and adaptive immunity Virulence factors Systemic fungal infection Fungal infection Coccidioidomycosis pathogenesis Fungal pathogenesis 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Neil M. Ampel and Susan E. Hoover declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.1-111 SAVAHCSTucsonUSA
  2. 2.Sanford HealthSioux FallsUSA

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