Current Fungal Infection Reports

, Volume 8, Issue 1, pp 21–36 | Cite as

Rare Fungal Infections in Children: An Updated Review of the Literature

  • Zoi Dorothea Pana
  • Katerina Vikelouda
  • Emmanuel Roilides
Pediatric Fungal Infections (T Lehrnbecher, Section Editor)

Abstract

An increasing trend of reports of rare fungal diseases has been observed to be mainly associated with the substantial increase of high-risk immunocompromised children, as well as with the selective pressure of antifungal drugs. On the other hand, recent reports have shown that several species of these rare fungi may also cause infections in immunocompetent children without obvious underlying conditions. The clinical spectrum of these infections, and most importantly their outcome, varies greatly, implying for a rather heterogenic group of pediatric infections. Various types of superficial and subcutaneous fungal infections, as well as systemic and disseminated life-threatening infections, have been reported. Prompt diagnosis and appropriate treatment of rare fungal diseases in children remains a great challenge. Several treatment options have been used, ranging from localized to combination treatment with extensive surgical excision and long-term antifungal therapy. We review contemporary data of rare fungal infections in pediatric patients focusing on epidemiology, mycology, management and outcome, published during the last three years.

Keywords

Zygomycetes Hyaline molds Dematiaceous fungi Rare yeast species Dimorphic fungal species Children 

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Jain A, Jain S, Rawat S. Emerging fungal infections among children: a review on its clinical manifestations, diagnosis, and prevention. J Pharm Bioallied Sci. 2010;2:314–20.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41:634–53.PubMedGoogle Scholar
  3. 3.
    Kwon-Chung KJ. Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectives. Clin Infect Dis. 2012;54:8–15.Google Scholar
  4. 4.
    Sujatha S, Sheeladevi C, Khyriem AB, et al. Subcutaneous zygomycosis caused by Basidiobolus ranarum - a case report. Indian J Med Microbiol. 2003;21:205–6.PubMedGoogle Scholar
  5. 5.
    Pandit V, Rhee P, Aziz H, et al. Perforated appendicitis with gastroinestinal basidiobolomycosis: A rare finding. Surg Infect. (Larchmt) 2013 [Epub ahead of print].Google Scholar
  6. 6.
    Prabhu RM, Patel R. Mucormycosis and Entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect. 2004;10:31–47.PubMedGoogle Scholar
  7. 7.
    Gugnani HC. A review of zygomycosis due to Basidiobolus ranarum. Eur J Epidemiol. 1999;15:923–9.PubMedGoogle Scholar
  8. 8.••
    Vikram HR, Smilack JD, Leighton JA, et al. Emergence of gastrointestinal basidiobolomycosis in the United States, with a review of worldwide cases. Clin Infect Dis. 2012;54:1685–91. This is a recently published large retrospective observational cohort study of 44 patients with gastrointestinal basidiobolomycosis, evaluating this emerging invasive fungal infection in desert regions of the US Southwest region.PubMedGoogle Scholar
  9. 9.
    Arjmand R, Karimi A, Sanaei Dashti A, et al. A child with intestinal basidiobolomycosis. Iran J Med Sci. 2012;37:134–6.PubMedCentralPubMedGoogle Scholar
  10. 10.
    Girish M, Arora A, Bhalla L, et al. Elephantine but not elephantiasis: subcutaneous zygomycosis. Indian J Pediatr. 2011;78:1142–4.PubMedGoogle Scholar
  11. 11.
    Anand M, Deshmukh SD, Pande DP, et al. Subcutaneous zygomycosis due to Basidiobolus ranarum: a case report from Maharastra, India. J Trop Med. 2010;2010:950390.PubMedCentralPubMedGoogle Scholar
  12. 12.
    Al-Shanafey S, AlRobean F, Bin Hussain I. Surgical management of gastrointestinal basidiobolomycosis in pediatric patients. J Pediatr Surg. 2012;47:949–51.PubMedGoogle Scholar
  13. 13.
    El-Shabrawi MH, Kamal NM. Gastrointestinal basidiobolomycosis in children: an overlooked emerging infection? J Med Mirobiol. 2011;60:871–80.Google Scholar
  14. 14.
    Arya AA, Naik C, Deshmukh S, et al. Mastoid infection caused by entomophthorales: a rare fungal disease. J Laryngol Otol. 2011;125:630–2.PubMedGoogle Scholar
  15. 15.
    Blazquez D, Ruiz-Contreras J, Fernandez-Cooke E, et al. Lichtheimia corymbifera subcutaneous infection successfully treated with amphotericin B, early debridement, and vacuum-assisted closure. J Pediatr Surg. 2010;45:13–5.Google Scholar
  16. 16.
    Gurevich M, Levi I, Steinberg R, et al. Mucormycosis in a liver allograft: salvage re transplantation and targeted immunosuppressive management. Transpl Infect Dis. 2012;14:97–101.Google Scholar
  17. 17.
    Velepic M, Manestar D, Ahel VV, et al. Mucormycosis of the nasal ala in a leukemic (M7 AML) child. Is surgery of the nasal defect indicated? Coll Anthropol. 2012;36:535–7.Google Scholar
  18. 18.
    Ting JY, Chan SY, Lung DC, et al. Intra-abdominal Rhizopus microsporus infection successfully treated by combined aggressive surgical, antifungal, and iron chelating therapy. J Pediatr Hematol Oncol. 2010;32:238–40.Google Scholar
  19. 19.
    Wildenbeest JG, Oomen MW, Bruggemann RJ, et al. Rhizopus oryzae skin infection treated with posaconazole in a boy with chronic granulomatous disease. Pediatr Infect Dis J. 2010;29:578.PubMedGoogle Scholar
  20. 20.••
    Matthias KR, Nix DE, Peloquin CA, et al. Poor absorption of high-dose posaconazole in pediatric bone marrow transplant patients. Ann Pharmacother. 2012;46(9):22. This study evaluates the safety of high-dose posaconazole in two pediatric patients undergoing bone marrow transplantation (BMT), highlighting concerns regarding posaconazole absorption in this patients’ group.Google Scholar
  21. 21.
    Dalgic B, Bukulmez A, Sari S. Pyogenic liver abscess and peritonitis due to Rhizopus oryzae in a child with Papillon-Lefevre syndrome. Eur J Pediatr. 2011;170:803–5.PubMedGoogle Scholar
  22. 22.
    Adderson EE, Rowland C, McGregor LM, et al. Zygomycosis originating from an odontogenic infection in a pediatric oncology patient. Diagn Microbiol Infect Dis. 2010;67:92–4.PubMedCentralPubMedGoogle Scholar
  23. 23.
    Taj-Aldeen SJ, Falamarzi A, AlMuzrkchi A, et al. Rare pediatric rhino-orbital infection caused by Saksenaea vasiformis. Infection. 2012;40:703–7.PubMedGoogle Scholar
  24. 24.
    Weng TF, Ho MW, Lin HC, et al. Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia. Pediatr Transplant. 2012;16:35–8.Google Scholar
  25. 25.
    Elguazzar S, Benouachane T, Nasri A, et al. Iliofemoral cutaneous mucormycosis with endopelvic extension in an immunocompetent child. Arch Pediatr. 2012;20:754–7.Google Scholar
  26. 26.
    Chakravarti A, Bhargava R, Bhattacharya S. Cutaneous mucormycosis of nose and facial region in children: a case series. Int J Pediatr Otorhinolaryngol. 2013;77:869–72.PubMedGoogle Scholar
  27. 27.
    Razouk S, Sebbani S, Agoumi A, et al. The subcutaneous mucormycosis due to Lichtheimia corymbifera: a case report in an immunocompetent child. J Mycol Med. 2012;22:185–8.PubMedGoogle Scholar
  28. 28.
    Kleinotiene G, Posiunas G, Raistenskis J, et al. Liposomal amphotericin B and surgery as successful therapy for pulmonary Lichtheimia corymbifera zygomycosis in a pediatric patient with acute promyelocytic leukemia on antifungal prophylaxis with posaconazole. Med Oncol. 2013;30:433.PubMedGoogle Scholar
  29. 29.
    Irga N, Kosiak W, Jaworski R, et al. Hyperthyroidism secondary to disseminated mucormycosis in a child with acute lymphoblastic leukemia: case report and a review of published reports. Mycopathologia. 2013;175:123–7.PubMedCentralPubMedGoogle Scholar
  30. 30.
    Rawal YB, Kalmar JR. Intraoral phaeohyphomycosis. Head Neck Pathol. 2012;6(4):481–5.PubMedCentralPubMedGoogle Scholar
  31. 31.
    Fathy H, Abdel-Razek MM, Abdelgaber S, et al. Subcutaneous phaeohyphomycosis in immunocompetent child caused by Exophiala jeanselmei. Int J Dermatol. 2012;51:1267–70.PubMedGoogle Scholar
  32. 32.
    Mudholkar VG, Acharya AS, Ramteke RV. Disseminated cutaneous phaeohyphomycosis in immunocompetent child. Pediatr Dermatol. 2011;28:30–1.PubMedGoogle Scholar
  33. 33.
    Madhugiri VS, Bhagavatula ID, Mahadevan A, et al. An unusual infection, an unusual outcome–Fonsecaea pedrosoi cerebral granuloma. J Neurosurg. 2011;8:229–32.Google Scholar
  34. 34.
    Gao LJ, Yu J, Wang DL, et al. Recalcitrant primary subcutaneous phaeohyphomycosis due to Phialophora verrucosa. Mycopathologia. 2013;175:165–70.PubMedGoogle Scholar
  35. 35.
    Sosa EE, Cohen PR, Tschen JA. Cladosporium scalp infection. Skinmed. 2012;10:393–4.PubMedGoogle Scholar
  36. 36.
    Cai Q, Lv GX, Jiang YQ, et al. The first case of phaeohyphomycosis caused by Rhinocladiella basitona in an immunocompetent child in China. Mycopathologia. 2013;176:101–5.PubMedGoogle Scholar
  37. 37.•
    Chowdhary A, Randhawa HS, Singh V, et al. Bipolaris hawaiiensis as etiologic agent of allergic bronchopulmonary mycosis: first case in a paediatric patient. Med Mycol. 2011;49:760–5. Although the most common etiologic pathogen associated with allergic bronchopulmonary mycosis (ABPM) is Aspergillus fumigatus, this report describes the first case of Bipolaris hawaiiensis causing ABPM in a paediatric patient.PubMedGoogle Scholar
  38. 38.
    Juhas E, Reyes-Mugica M, Michaels MG, et al. Exserohilum infection in an immunocompromised neonate. Pediatr Dermatol. 2013;6:232–3.Google Scholar
  39. 39.
    Pradeepkumar NS, Joseph NM. Chromoblastomycosis caused by Cladophialophora carrionii in a child from India. J Infect Dev Ctries. 2011;5:556–60.PubMedGoogle Scholar
  40. 40.
    Matlani M, Kaur R. Shweta. A case of Scedosporium prolificans osteomyelitis in an immunocompetent child, misdiagnosed as tubercular osteomyelitis. Indian J Dermatol. 2013;58:80–1.PubMedCentralPubMedGoogle Scholar
  41. 41.
    Song MJ, Lee JH, Lee NY. Fatal Scedosporium prolificans infection in a paediatric patient with acute lymphoblastic leukaemia. Mycoses. 2011;54:81–3.PubMedGoogle Scholar
  42. 42.
    Kendirli T, Ciftci E, Ekim M, et al. Acremonium spp. peritonitis in an infant. Mycoses. 2008;51:455–7.PubMedGoogle Scholar
  43. 43.
    Yan X, Yu C, Shi Z, et al. Nasal cutaneous infection in a healthy boy caused by Fusarium moniliforme. Pediatr Dermatol. 2013;30:43–5.Google Scholar
  44. 44.
    Morel LN, Cid PM, De Celada RM, et al. Disseminated fusariosis in a pediatric population. Pediatr Dermatol. 2013;30:255–6.Google Scholar
  45. 45.
    Silva GM, Silveira AR, Betania CA, et al. Disseminated fusariosis secondary to neuroblastoma with fatal outcome. Mycopathologia. 2013;176:233–6.PubMedGoogle Scholar
  46. 46.
    Gluck O, Segal N, Yariv F, et al. Pediatric invasive sinonasal Scopulariopsis brevicaulis–a case report and literature review. Int J Pediatr Otorhinolaryngol. 2011;75:891–3.PubMedGoogle Scholar
  47. 47.
    Petit A, Levine E, Epaud R, et al. Scopulariopsis brevicaulis abscess in a child treated for myeloblastic leukaemia. Lancet Infect Dis. 2011;11:416.PubMedGoogle Scholar
  48. 48.
    Roehm CE, Salazar JC, Hagstrom N, et al. Phoma and Acremonium invasive fungal rhinosinusitis in congenital acute lymphocytic leukemia and literature review. Int J Pediatr Otorhinolaryngol. 2012;76:1387–91.PubMedGoogle Scholar
  49. 49.••
    Lee PP, Chan KW, Lee TL, et al. Penicilliosis in children without HIV infection–are they immunodeficient? Clin Infect Dis. 2012;54:8–19. Interesting contemporary data regarding pediatric patients with penicilliosis without HIV infection. Penicilliosis should be regarded as an indicator for underlying immunodeficiency in HIV-negative individuals.Google Scholar
  50. 50.
    Sudjaritruk T, Sirisanthana T, Sirisanthana V. Immune reconstitution inflammatory syndrome from Penicillium marneffei in an HIV-infected child: a case report and review of literature. BMC Infect Dis. 2012;12:28.PubMedCentralPubMedGoogle Scholar
  51. 51.
    Hitoto H, Pihet M, Weil B, et al. Acremonium strictum fungaemia in a paediatric immunocompromised patient: diagnosis and treatment difficulties. Mycopathologia. 2010;170:161–4.PubMedGoogle Scholar
  52. 52.
    Santillan Salas CF, Joshi AY, Dhiman N, et al. Fatal post-operative Trichoderma longibrachiatum mediastinitis and peritonitis in a paediatric patient with complex congenital cardiac disease on peritoneal dialysis. J Med Microbiol. 2013;60:1869–71.Google Scholar
  53. 53.
    Yuanjie Z, Jianghan C, Nan X, et al. Cryptococcal meningitis in immunocompetent children. Mycoses. 2012;55:168–71.PubMedGoogle Scholar
  54. 54.
    Debourgogne A, Hagen F, Elenga N, et al. Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region. Rev Iberoam Micol. 2012;29:210–3.PubMedGoogle Scholar
  55. 55.
    Molina-Leyva A, Ruiz-Carrascosa JC, Leyva-Garcia A, et al. Cutaneous Cryptococcus laurentii infection in an immunocompetent child. Int J Infect Dis. 2013;17:1232–3.Google Scholar
  56. 56.
    Friedman D, Kongthavonsakul K, Oberdorfer P. Disseminated cryptococcosis in an HIV-positive boy. BMJ Case Rep. 2012. doi:10.1136/bcr-2012-007036.PubMedGoogle Scholar
  57. 57.
    Heath JL, Yin DE, Wechsler DS, et al. Successful treatment of disseminated cryptococcal infection in a pediatric acute lymphoblastic leukemia patient during induction. J Pediatr Hematol Oncol. 2012;34:161–3.Google Scholar
  58. 58.
    Nagotkar L, Shanbag P, Mauskar A, et al. Fulminant intracranial hypertension due to cryptococcal meningitis in a child with nephrotic syndrome. Indian J Crit Care Med. 2011;15:176–8.PubMedCentralPubMedGoogle Scholar
  59. 59.
    Natukunda E, Musiime V, Ssali F, et al. A case of cryptococcal lymphadenitis in an HIV-infected child. AIDS Res Hum Retrovir. 2011;27:373–6.PubMedGoogle Scholar
  60. 60.
    Pinto Junior VL, Pone MV, Pone SM, et al. Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case. Rev Soc Bras Med Trop. 2010;43:746–8.PubMedGoogle Scholar
  61. 61.
    Prakash A, Wankhede S, Singh PK, et al. First neonatal case of fungaemia due to Pseudozyma aphidis and a global literature review. Mycoses. 2013. doi:10.1111/myc.12098.Google Scholar
  62. 62.
    Dua V, Yadav SP, Oberoi J, et al. Successful treatment of Trichosporon asahii infection with voriconazole after bone marrow transplant. J Pediatr Hematol Oncol. 2013;35:237–8.PubMedGoogle Scholar
  63. 63.
    Ozkaya-Parlakay A, Cengiz AB, Karadag-Oncel E, et al. Geotrichum capitatum septicemia in a hematological malignancy patient with positive galactomannan antigen: case report and review of the literature. Turk J Pediatr. 2012;54:674–8.PubMedGoogle Scholar
  64. 64.
    Ozkaya-Parlakay A, Karadag-Oncel E, Cengiz AB, et al. Trichosporon asahii sepsis in a patient with pediatric malignancy. J Microbiol Immunol Infect. 2013. doi:10.1016/j.jmii.2013.01.003.PubMedGoogle Scholar
  65. 65.
    Zahn M, Hesson M, Morton R, et al. Granulomatous pleuritis caused by histoplasmosis in a healthy child. Pediatr Pulmonol. 2011;46:729–31.PubMedGoogle Scholar
  66. 66.
    Pereira GH, Santos AQ, Park M, et al. Bone marrow involvement in a patient with paracoccidioidomycosis: a rare presentation of juvenile form. Mycopathologia. 2010;170:259–61.PubMedGoogle Scholar
  67. 67.
    Schuster JE, Wushensky CA, Di Pentima MC. Chronic primary central nervous system histoplasmosis in a healthy child with intermittent neurological manifestations. Pediatr Infect Dis J. 2013;32:794–6.PubMedGoogle Scholar
  68. 68.
    Threlkeld ZD, Broughton R, Khan GQ, et al. Isolated Histoplasma capsulatum meningoencephalitis in an immunocompetent child. J Child Neurol. 2013;27:532–5.Google Scholar
  69. 69.
    Dhawan J, Verma P, Sharma A, et al. Disseminated cutaneous histoplasmosis in an immunocompetent child, relapsed with itraconazole, successfully treated with voriconazole. Pediatr Dermatol. 2012;27:549–51.Google Scholar
  70. 70.•
    Brick KE, Drolet BA, Lyon VB, et al. Cutaneous and disseminated blastomycosis: a pediatric case series. Pediatr Dermatol. 2013;30:23–8. A recently published retrospective analysis of 17 pediatric cases of blastomycosis diagnosed from 1999 to 2009.PubMedGoogle Scholar
  71. 71.
    Abrams E, Dean HJ, Bunge MK, et al. Blastomycosis of the central nervous system in a child: a rare cause of hypopituitarism. J Pediatr Endocrinol Metab. 2011;24:775–7.PubMedGoogle Scholar
  72. 72.
    Motswaledi HM, Monyemangene FM, Maloba BR, et al. Blastomycosis: a case report and review of the literature. Int J Dermatol. 2012;51:1090–3.PubMedGoogle Scholar
  73. 73.
    Freitas DF, Lima IA, Curi CL, et al. Acute dacryocystitis: another clinical manifestation of sporotrichosis. Mem Inst Oswaldo Cruz. 2013;108:909–13.Google Scholar
  74. 74.••
    Song Y, Yao L, Zhong SX, et al. Infant sporotrichosis in northeast China: a report of 15 cases. Int J Dermatol. 2011;50:522–9. This is one of the largest case series of infant sporotrichosis.PubMedGoogle Scholar
  75. 75.•
    Saadah OI, Farouq MF, Daajani NA, et al. Gastrointestinal basidiobolomycosis in a child; an unusual fungal infection mimicking fistulising Crohn's disease. J Crohn's Colitis. 2012;6:368–72. This case report is of high clinical interest because it represents the difficulty in diagnosing gastrointestinal basidiobolomycosis in children, as this condition may mimic several other pathologic conditions, like Crohn’s colitis.Google Scholar
  76. 76.
    Yousef OM, Smilack JD, Kerr DM, et al. Gastrointestinal basidiobolomycosis. Morphologic findings in a cluster of six cases. Am J Clin Pathol. 1999;112:610–6.PubMedGoogle Scholar
  77. 77.
    Hussein MR, Musalam AO, Assiry MH, et al. Histological and ultrastructural features of gastrointestinal basidiobolomycosis. Mycol Res. 2007;111:926–30.PubMedGoogle Scholar
  78. 78.
    Azie N, Neofytos D, Pfaller M, et al. The PATH (Prospective Antifungal Therapy) Alliance(R) registry and invasive fungal infections: update 2012. Diagn Microbiol Infect Dis. 2012;73:293–300.PubMedGoogle Scholar
  79. 79.
    Roilides E, Zaoutis TE, Katragkou A, et al. Zygomycosis in neonates: an uncommon but life-threatening infection. Am J Perinatol. 2009;26:565–73.PubMedGoogle Scholar
  80. 80.
    Roilides E, Zaoutis TE, Walsh TJ. Invasive zygomycosis in neonates and children. Clin Microbiol Infect. 2009;15:50–4.PubMedGoogle Scholar
  81. 81.••
    Dabritz J, Attarbaschi A, Tintelnot K, et al. Mucormycosis in paediatric patients: demographics, risk factors and outcome of 12 contemporary cases. Mycoses. 2012;54:785–8. This is a recently published case series of pediatric mucormycosis from Germany and Austria during 2004–2008.Google Scholar
  82. 82.
    Almaslamani M, Taj-Aldeen SJ, Garcia-Hermoso D, et al. An increasing trend of cutaneous zygomycosis caused by Mycocladus corymbifer (formerly Absidia corymbifera): report of two cases and review of primary cutaneous Mycocladus infections. Med Mycol. 2009;47:532–8.PubMedGoogle Scholar
  83. 83.
    Spellberg B, Walsh TJ, Kontoyiannis DP, et al. Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis. 2009;48:1743–51.PubMedCentralPubMedGoogle Scholar
  84. 84.
    Garbino J, Uckay I, Amini K, et al. Absidia posttraumatic infection: successful treatment with posaconazole. J Infect. 2005;51:135–8.Google Scholar
  85. 85.
    Rickerts V, Atta J, Herrmann S, et al. Successful treatment of disseminated mucormycosis with a combination of liposomal amphotericin B and posaconazole in a patient with acute myeloid leukaemia. Mycoses. 2006;49:27–30.PubMedGoogle Scholar
  86. 86.••
    Vehreschild JJ, Birtel A, Vehreschild MJ, et al. Mucormycosis treated with posaconazole: review of 96 case reports. Crit Rev Microbiol. 2013;39:310–24. This review article focuses on reports of patients with mucormycosis treated with posaconazole either as combination or salvage therapy.PubMedGoogle Scholar
  87. 87.
    Tarani L, Costantino F, Notheis G, et al. Long-term posaconazole treatment and follow-up of rhino-orbital-cerebral mucormycosis in a diabetic girl. Pediatr Diabetes. 2009;10:289–93.PubMedGoogle Scholar
  88. 88.
    Baradkar VP, Kumar S. Cutaneous zygomycosis due to Saksenaea vasiformis in an immunocompetent host. Indian J Dermatol. 2009;54:382–4.PubMedCentralPubMedGoogle Scholar
  89. 89.
    Solano T, Atkins B, Tambosis E, et al. Disseminated mucormycosis due to Saksenaea vasiformis in an immunocompetent adult. Clin Infect Dis. 2000;30:942–3.PubMedGoogle Scholar
  90. 90.
    Trotter DJ, Gonis G, Cottrill E, et al. Disseminated Saksenaea vasiformis in an immunocompetent host. Med J Aust. 2008;189:519–20.PubMedGoogle Scholar
  91. 91.
    Bearer EA, Nelson PR, Chowers MY, et al. Cutaneous zygomycosis caused by Saksenaea vasiformis in a diabetic patient. J Clin Microbiol. 1994;32:1823–4.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Gonis G, Starr M. Fatal rhinoorbital mucormycosis caused by Saksenaea vasiformis in an immunocompromised child. Pediatr Infect Dis J. 1997;16:714–6.PubMedGoogle Scholar
  93. 93.
    Kompoti M, Michalia M, Kallitsi G, et al. Fatal cutaneous Saksenaea vasiformis infection in a critically ill trauma patient. Mycoses. 2011;54:599–601.Google Scholar
  94. 94.
    Revankar SG. Phaeohyphomycosis. Infect Dis Clin N Am. 2006;20:609–20.Google Scholar
  95. 95.
    Revankar SG, Patterson JE, Sutton DA, et al. Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis. 2002;34:467–76.PubMedGoogle Scholar
  96. 96.
    Joseph NM, Kumar MA, Stephen S, et al. Keratomycosis caused by Exserohilum rostratum. Indian J Pathol Microbiol. 2012;55:248–9.PubMedGoogle Scholar
  97. 97.
    Revankar SG. Dematiaceous fungi. Mycoses. 2007;50:91–101.PubMedGoogle Scholar
  98. 98.••
    Tortorano AM RM, et al. Guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp, Scedosporium spp, and others. Clin Microbiol Infect. 2013 (in press). Most recently updated European guidelines on diagnosis and management of various forms of hyalohyphomycosis, such as those due to Fusarium spp. and Scedosporium spp.Google Scholar
  99. 99.
    Brandt ME, Warnock DW. Epidemiology, clinical manifestations, and therapy of infections caused by dematiaceous fungi. J Chemother. 2003;15:36–47.PubMedGoogle Scholar
  100. 100.
    Walsh TJ, Groll A, Hiemenz J, et al. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect. 2004;10:48–66.PubMedGoogle Scholar
  101. 101.
    Cuenca-Estrella M, Gomez-Lopez A, Mellado E, et al. Scopulariopsis brevicaulis, a fungal pathogen resistant to broad-spectrum antifungal agents. Antimicrob Agents Chemother. 2003;47:2339–41.PubMedCentralPubMedGoogle Scholar
  102. 102.
    Stein LL, Adams EG, Holcomb KZ. Inflammatory tinea capitis mimicking dissecting cellulitis in a postpubertal male: a case report and review of the literature. Mycoses. 2013;56:596.PubMedGoogle Scholar
  103. 103.
    Ruan SY, Chien JY, Hsueh PR. Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan. Clin Infect Dis. 2009;49:11–7.Google Scholar
  104. 104.••
    Arendrup MC BT, Boekhout T, Akova M, et al. Joint ESCMID/ECMM guideline for the diagnosis and management of rare invasive yeast infections. Clin Microbiol Infect. 2013. doi:10.1111/1469-0691.12360. Excellent document of updated guidelines for the diagnosis and management of emerging invasive yeast infections.Google Scholar
  105. 105.
    Klein BS, Tebbets B. Dimorphism and virulence in fungi. Curr Opin Microbiol. 2007;10:314–9.PubMedCentralPubMedGoogle Scholar
  106. 106.
    de Melo Braga G, Hessel G, Pereira RM. Hepatic involvement in pediatric patients with paracoccidioidomycosis: a clinical and laboratory study. Mycopathologia. 2013. doi:10.1111/his.12244.Google Scholar
  107. 107.
    Chu JH, Feudtner C, Heydon K, et al. Hospitalizations for endemic mycoses: a population-based national study. Clin Infect Dis. 2006;42:822–5.PubMedGoogle Scholar
  108. 108.
    Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:807–25.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zoi Dorothea Pana
    • 1
  • Katerina Vikelouda
    • 1
  • Emmanuel Roilides
    • 1
    • 2
  1. 1.Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Medicine, School of Health SciencesAristotle UniversityThessalonikiGreece
  2. 2.3rd Department of Pediatrics, Hippokration HospitalThessalonikiGreece

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