Current Fungal Infection Reports

, Volume 7, Issue 3, pp 192–197 | Cite as

Candida africana: Is It a Fungal Pathogen?

  • Orazio Romeo
  • Hans-Jürgen Tietz
  • Giuseppe Criseo
Clinical Lab Issues (M Brandt, Section Editor)


Twelve years ago, Candida africana was proposed as new species within the Candida albicans species complex, and since then has raised much controversy regarding whether or not it should be considered a separate species from C. albicans. Although its taxonomic status is still a matter of debate, this yeast differs from C. albicans by a number of phenotypic, genotypic, pathogenic and clinical characteristics that make this fungus particularly interesting to study. Current epidemiological and clinical data suggest that C. africana has a worldwide distribution, is particularly adapted to colonize/infect human vaginal mucosa, and may also be responsible for most serious diseases involving other human organs. In this review, we will discuss the current knowledge about C. africana, highlighting its role in human infections, thus providing a complete clinical picture in order to understand if this yeast can be considered an important pathogen.


Candidiasis Candida africana Candida albicans Candida dubliniensis Chlamydospore negative Atypical Candida strains Molecular identification Epidemiology Vaginal infections Vaginitis Antifungals 


Compliance with Ethics Guidelines

Conflict of Interest

Orazio Romeo declares that he has no conflict of interest.

Hans-Jürgen Tietz declares that he has no conflict of interest.

Giuseppe Criseo declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Orazio Romeo
    • 1
  • Hans-Jürgen Tietz
    • 2
  • Giuseppe Criseo
    • 1
  1. 1.Department of Environmental and Biological SciencesUniversity of MessinaMessinaItaly
  2. 2.Institut für PilzkrankheitenBerlinGermany

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