Current Fungal Infection Reports

, Volume 7, Issue 2, pp 89–95 | Cite as

Influence of Serum and Albumin on Echinocandin In Vitro Potency and Pharmacodynamics

  • Aasya Nasar
  • Laurajo Ryan
  • Christopher R. Frei
  • Jason M. Cota
  • Nathan P. Wiederhold
Pharmacology and Pharmacodynamics of Antifungal Agents (P Gubbins, Section Editor)

Abstract

The echinocandins target fungi by inhibiting the production of (1,3)-β-d-glucan, an essential component of the fungal cell wall. These agents have less toxicity to mammalian cells, as compared to other antifungals; however, they maintain potent activity against many pathogenic fungi, including polyene- and azole-resistant isolates. Members of this class are highly protein-bound, and the addition of serum or albumin to the growth medium has profound effects on their in vitro potency and pharmacodynamics. In addition, studies have demonstrated an association between in vitro activity, in the presence of serum, and outcomes in animal models of invasive fungal infections. Serum and albumin may also be useful to help detect echinocandin-resistant Candida isolates with point mutations in the gene that encodes for glucan synthase. Thus, in vitro studies evaluating echinocandins in the presence of protein can provide valuable insight regarding their potency and pharmacodynamics.

Keywords

Echinocandins Serum Albumin Protein binding Caspofungin Anidulafungin Micafungin 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Aasya Nasar
    • 1
    • 2
  • Laurajo Ryan
    • 1
    • 2
  • Christopher R. Frei
    • 1
    • 2
  • Jason M. Cota
    • 3
  • Nathan P. Wiederhold
    • 1
    • 2
  1. 1.University of Texas at Austin College of PharmacyAustinUSA
  2. 2.Pharmacotherapy Education and Research CenterUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  3. 3.University of the Incarnate Word Feik School of PharmacySan AntonioUSA

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