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Susceptibility testing of dermatophytes

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Abstract

The dermatophytes are a specialized group of fungi that infect the keratinized tissues of humans (hair, nails, and skin) and cause superficial infections. Although several studies have been conducted to develop methods to determine the susceptibilities of yeast and filamentous fungi, similar studies for dermatophytes have only recently taken place. We review how susceptibility testing of dermatophytes was developed and how it has already been applied to clinical samples. We also review recent advances in the development of disk diffusion and colorimetric methodologies for determining the antifungal susceptibility of dermatophytes. With several agents now available for treating infections due to dermatophytes, susceptibility testing will serve as a valuable tool for clinicians as they choose the most appropriate treatment option. Studies are still needed to establish interpretive breakpoints for antifungal agents used in the treatment of superficial fungal infections.

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Correspondence to Mahmoud A. Ghannoum.

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Ghannoum, M.A., Isham, N.C. & Chand, D.V. Susceptibility testing of dermatophytes. Curr Fungal Infect Rep 3, 142–146 (2009). https://doi.org/10.1007/s12281-009-0018-6

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