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Host—microbial interactions in metabolic diseases: from diet to immunity

Journal of Microbiology volume 60, pages 561–575 (2022)Cite this article

Abstract

Growing evidence suggests that the gut microbiome is an important contributor to metabolic diseases. Alterations in microbial communities are associated with changes in lipid metabolism, glucose homeostasis, intestinal barrier functions, and chronic inflammation, all of which can lead to metabolic disorders. Therefore, the gut microbiome may represent a novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic fatty liver disease. This review discusses how gut microbes and their products affect metabolic diseases and outlines potential treatment approaches via manipulation of the gut microbiome. Increasing our understanding of the interactions between the gut microbiome and host metabolism may help restore the healthy symbiotic relationship between them.

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Acknowledgements

This study was supported by the Suh Kyungbae Foundation. Figures were created with BioRender.com.

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  1. School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, 08826, Republic of Korea

    Ju-Hyung Lee & Joo-Hong Park

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  1. Ju-Hyung Lee
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JHP conceived the study; JHL and JHP wrote and revised the manuscript. All authors approved the final manuscript.

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Correspondence to Joo-Hong Park.

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Lee, JH., Park, JH. Host—microbial interactions in metabolic diseases: from diet to immunity. J Microbiol. 60, 561–575 (2022). https://doi.org/10.1007/s12275-022-2087-y

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Keywords

  • microbiome
  • obesity
  • metabolic disease
  • lipid
  • inflammation