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Effects of multi-species probiotic supplementation on alcohol metabolism in rats

Journal of Microbiology volume 59, pages 417–425 (2021)Cite this article

An Erratum to this article was published on 28 April 2021

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Abstract

Probiotics are known to protect against liver damage induced by the alcohol and acetaldehyde accumulation associated with alcohol intake. However, there have been few studies of the direct effect of probiotics on alcohol metabolism, and the types of probiotics that were previously analyzed were few in number. Here, we investigated the effects of 19 probiotic species on alcohol and acetaldehyde metabolism. Four probiotic species that had a relatively high tolerance to alcohol and metabolized alcohol and acetaldehyde effectively were identified: Lactobacillus gasseri CBT LGA1, Lactobacillus casei CBT LC5, Bifidobacterium lactis CBT BL3, and Bifidobacterium breve CBT BR3. These species also demonstrated high mRNA expression of alcohol and acetaldehyde dehydrogenases. ProAP4, a mixture of these four probiotics species and excipient, was then administered to rats for 2 weeks in advance of acute alcohol administration. The serum alcohol and acetaldehyde concentrations were significantly lower in the ProAP4-administered group than in the control and excipient groups. Thus, the administration of ProAP4, containing four probiotic species, quickly lowers blood alcohol and acetaldehyde concentrations in an alcohol and acetaldehyde dehydrogenasedependent manner. Furthermore, the serum alanine aminotransferase activity, which is indicative of liver damage, was significantly lower in the ProAP4 group than in the control group. The present findings suggest that ProAP4 may be an effective means of limiting alcohol-induced liver damage.

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Authors and Affiliations

  1. R&D Center, Cell Biotech, Co., Ltd., 50, Aegibong-ro 409 beon-gil, Gaegok-ri, Wolgot-myeon, Gimpo-si, 10003, Republic of Korea

    Tae-Joong Lim, Sanghyun Lim, Jong Hyun Yoon & Myung Jun Chung

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  1. Tae-Joong Lim
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  2. Sanghyun Lim
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  3. Jong Hyun Yoon
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  4. Myung Jun Chung
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Correspondence to Myung Jun Chung.

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Lim, TJ., Lim, S., Yoon, J.H. et al. Effects of multi-species probiotic supplementation on alcohol metabolism in rats. J Microbiol. 59, 417–425 (2021). https://doi.org/10.1007/s12275-021-0573-2

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  • DOI: https://doi.org/10.1007/s12275-021-0573-2

Keywords

  • probiotic
  • alcohol
  • alcohol dehydrogenase
  • aldehyde dehydrogenase
  • alanine aminotransferase
  • hangover