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Metformin capped Cu2(OH)3Cl nanosheets for chemodynamic wound disinfection

Abstract

Recently, the development of chemodynamic therapy (CDT) offers a potential approach for fighting bacteria and treating infectious diseases, in which those CDT nanoagents can catalyze the generation of hydroxyl radicals (•OH) to destroy bacteria. In this work, to improve the efficiency of CDT, we have designed a new kind of metformin (Met)-capped two-dimensional Cu2(OH)3Cl nanosheets (CuOHCl-Met NSs) with good monodispersity, highly positive charge, and good biocompatibility for improving antibacterial effect and accelerating wound healing. With the capped Met, CuOHCl-Met NSs can effectively kill bacteria under a low concentration (6 µg·mL−1) and a short treatment time (in 15 min), showing great advantages over the counterpart without Met. In vivo results demonstrated that CuOHCl-Met NSs accelerated the tissue regeneration of staphylococcus aureus-infected dermal wounds. This study provides a new pathway for improving efficiency of CDT nanoagent through using old drug.

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Acknowledgements

The work was supported by the National Natural Science Foundation of China (Nos. 82072065 and 81471784), and the National Youth Talent Support Program.

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Correspondence to Shu Yan or Linlin Li.

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Wang, X., Wang, S., Gao, J. et al. Metformin capped Cu2(OH)3Cl nanosheets for chemodynamic wound disinfection. Nano Res. (2022). https://doi.org/10.1007/s12274-022-4457-5

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  • DOI: https://doi.org/10.1007/s12274-022-4457-5

Keywords

  • chemodynamic therapy
  • metformin
  • antibacterial effect
  • wound healing
  • drug repositioning