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Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration

Abstract

Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules, such as bone morphogenetic proteins, are desired for bone regeneration. Herein, we report the development of mesoporous silica rods with large cone-shaped pores (MSR-CP) to load and deliver large protein drugs. It is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated macrophage. Furthermore, bone morphogenetic proteins 2 (BMP-2) loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal cells. In vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration performance. This study provides a potential strategy for the design of drug delivery systems for bone regeneration.

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Acknowledgements

The authors acknowledge the support from UQ Early Career Researcher Grant (1717673) and the National Natural Science Foundation of China (Nos. 81871503 and 81701032). C. X. acknowledges the support of National Health & Medical Research Council of Australia (NHMRC) Early Career Fellowship. Y. H., L. X. and C. L. extended their appreciations to the support of Advanced Queensland. The authors acknowledge the support from the Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, the University of Queensland.

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Correspondence to Ali Khademhosseini or Qingsong Ye.

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Xu, C., Xiao, L., Cao, Y. et al. Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration. Nano Res. 13, 2323–2331 (2020). https://doi.org/10.1007/s12274-020-2783-z

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Keywords

  • mesoporous silica rod
  • bone regeneration
  • cone shaped pores
  • morphogenetic proteins 2 (BMP-2) delivery
  • osteoimmunomodulation