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Nano Research

, Volume 11, Issue 11, pp 6086–6101 | Cite as

Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

  • Yuwei He
  • Ruixiang Li
  • Jianming Liang
  • Ying Zhu
  • Shuya Zhang
  • Zicong Zheng
  • Jing Qin
  • Zhiqing PangEmail author
  • Jianxin WangEmail author
Research Article

Abstract

The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification, are complex, laborious, and inefficient. Inspired by the intrinsic relationship between platelets and RA, platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA. Through platelet receptor-mediated adhesion, an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanoparticles, endowing the resulting PNPs with various functional receptors. By coating with platelet membranes, the nanoparticles were stabilized and had a better circulation profile, providing a benefit for passive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition, indicating that the PNPs could effectively target to RA tissues through multiple mechanisms, similar to natural platelets. Moreover, FK506, a model drug, was loaded into the PNPs and used to treat RA. Pharmacodynamic studies demonstrated that the FK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides a new biomimetic targeting strategy with great potential for the treatment of RA.

Keywords

biomimetic nanoparticles platelet membrane rheumatoid arthritis targeted drug delivery 

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Notes

Acknowledgements

We acknowledge the financial support of the National Natural Science Foundation of China (Nos. 81690263, 81472757, 81361140344, 81773283, and 81773911). Thanks are given to Dr. Yang Yang from Shanghai University of Traditional Chinese Medicine for his kind help with the CIA model.

Supplementary material

12274_2018_2126_MOESM1_ESM.pdf (620 kb)
Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

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Copyright information

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yuwei He
    • 1
  • Ruixiang Li
    • 1
  • Jianming Liang
    • 1
    • 2
  • Ying Zhu
    • 1
    • 2
  • Shuya Zhang
    • 1
  • Zicong Zheng
    • 1
  • Jing Qin
    • 1
  • Zhiqing Pang
    • 1
    Email author
  • Jianxin Wang
    • 1
    Email author
  1. 1.Department of Pharmaceutics, School of PharmacyFudan University & Key Laboratory of Smart Drug Delivery, Ministry of EducationShanghaiChina
  2. 2.Institute of Clinical PharmacologyGuangzhou University of Traditional Chinese MedicineGuangzhouChina

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