Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with photo-triggered drug delivery enhance cell killing in drug-resistant breast cancer cells
- 395 Downloads
Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with high uniformity and monodispersity were designed and synthesized, in order to provide a photo-triggered strategy for drug-resistant cancer therapy. Under near-infrared laser irradiation, the nanospheres transformed laser power into local heat and reactive oxygen species via the connected indocyanine green molecule, thus exhibiting photothermal and photodynamic effects. Moreover, the photo-triggered drug release based on calcium-assisted silica degradation was observed, endowing the nanospheres with chemotherapeutic properties. Finally, combined therapeutic effects against drug-resistant human breast cancer cells were successfully obtained. These photo-triggered materials based on calcium carbonate could provide a promising platform for enhanced multimodal cancer therapies.
Keywordscalcium carbonate-based structures photothermal therapy photodynamic therapy combined therapeutic effects
Unable to display preview. Download preview PDF.
We acknowledge the funding support from the National Natural Science Foundation of China (Nos. 21431006, 21761132008, and 21501163), the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (No. 21521001), Key Research Program of Frontier Sciences, CAS (No. QYZDJ-SSW-SLH036), the National Basic Research Program of China (No. 2014CB931800), the Users with Excellence and Scientific Research Grant of Hefei Science Center of CAS (No. 2015HSC-UE007), and Anhui Provincial Natural Science Foundation (No. 1608085QB25).
- Smith, J. M. Adverse reactions to food and drug additives. Eur. J. Clin. Nutr. 1991, 45 Suppl 1, 17–21.Google Scholar
- Kong, F.; Zhang, H. B.; Zhang, X.; Liu, D. F.; Chen, D.; Zhang, W. X.; Zhang, L. Y.; Santos, H. A.; Hai, M. T. Biodegradable photothermal and pH responsive calcium carbonate@phospholipid@acetalated dextran hybrid platform for advancing biomedical applications. Adv. Funct. Mater. 2016, 26, 6158–6169.CrossRefGoogle Scholar
- Overgaard, J. Combined adriamycin and hyperthermia treatment of a murine mammary carcinoma in vivo. Cancer Res. 1976, 36, 3077–3081.Google Scholar
- Song, X. R.; Wang, X. Y.; Yu, S. X.; Cao, J. B.; Li, S. H.; Li, J.; Liu, G.; Yang, H. H.; Chen, X. Y. Co9Se8 nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy. Adv. Mater. 2015, 27, 3285–3291.CrossRefGoogle Scholar
- Zheng, M. B.; Yue, C. X.; Ma, Y. F.; Gong, P.; Zhao, P. F.; Zheng, C. F.; Sheng, Z. H.; Zhang, P. F.; Wang, Z. H.; Cai, L. T. Single-step assembly of DOX/ICG loaded lipidpolymer nanoparticles for highly effective chemo-photothermal combination therapy. ACS Nano 2013, 7, 2056–2067.CrossRefGoogle Scholar
- Wang, L. M.; Lin, X. Y.; Wang, J.; Hu, Z. J.; Ji, Y. L.; Hou, S.; Zhao, Y. L.; Wu, X. C.; Chen, C. Y. Novel insights into combating cancer chemotherapy resistance using a plasmonic nanocarrier: Enhancing drug sensitiveness and accumulation simultaneously with localized mild photothermal stimulus of femtosecond pulsed laser. Adv. Funct. Mater. 2014, 24, 4229–4239.CrossRefGoogle Scholar