Multifunctional core/satellite polydopamine@Nd3+-sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy
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Significant attenuation and overheating, caused by the absorption of the excitation band (980 nm) in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles (UCNPs). Therefore, appropriately-structured Nd3+-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core–shell–shell structured Nd3+-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine (PDA) to construct a novel multifunctional core/satellite nanotheranostic (PDA@UCNPs) for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core–shell–shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio-application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.
KeywordsNd3+-sensitized upconversion nanoparticles dual-modality imaging photothermal therapy multifunctional theranostic platform biocompatibility
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This work was supported by the financial aid from the National Natural Science Foundation of China (Nos. 51502284, 51372242, 51402286, 21521092, 21590794, and 21210001), the Hong Kong, Macao and Taiwan Science and Technology Cooperation Special Project of Ministry of Science and Technology of China (No. 2014DFT10310), the Program of Science and Technology Development Plan of Jilin Province of China (No. 20140201007GX), the National Basic Research Program of China (No. 2014CB643802), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20030300) and the Jilin Province Youth Foundation (No. 20150520007JH).
- Tian, Q. W.; Tang, M. H.; Sun, Y. G.; Zou, R. J.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv. Funct. Mater. 2011, 23, 3542–3547.CrossRefGoogle Scholar
- Tian, Q. W.; Jiang, F. R.; Zou, R. J.; Liu, Q.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic Cu9S5 nanocrystals: A photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 2011, 5, 9761–9771.CrossRefGoogle Scholar
- Stritzker, J.; Kirscher, L.; Scadeng, M.; Deliolanis, N. C.; Morscher, S.; Symvoulidis, P.; Schaefer, K.; Zhang, Q.; Buckel, L.; Hess, M. et al. Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer. Proc. Natl. Acad. Sci. USA 2013, 110, 3316–3320.CrossRefGoogle Scholar
- Ni, D. L.; Zhang, J. W.; Bu, W. B.; Zhang, C.; Yao, Z. W.; Xing, H. Y.; Wang, J.; Duan, F.; Liu, Y. Y.; Fan, W. P. et al. PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging. Biomaterials 2016, 76, 218–225.CrossRefGoogle Scholar
- Zhan, Q. Q.; Qian, J.; Liang, H. J.; Somesfalean, G.; Wang, D.; He, S. L.; Zhang, Z. G.; Andersson-Engels, S. Using 915 nm laser excited Tm3+/Er3+/Ho3+-doped NaYbF4 upconversion nanoparticles for in vitro and deeper in vivo bioimaging without overheating irradiation. ACS Nano 2011, 5, 3744–3757.CrossRefGoogle Scholar
- Zhong, Y. T.; Tian, G.; Gu, Z. J.; Yang, Y. J.; Gu, L.; Zhao, Y. L.; Ma, Y.; Yao, J. N. Elimination of photon quenching by a transition layer to fabricate a quenching-shield sandwich structure for 800 nm excited upconversion luminescence of Nd3+-sensitized nanoparticles. Adv. Mater. 2014, 26, 2831–2837.CrossRefGoogle Scholar
- Liu, B.; Chen, Y. Y.; Li, C. X.; He, F.; Hou, Z. Y.; Huang, S. S.; Zhu, H. M.; Chen, X. Y.; Lin, J. Poly(acrylic acid) modification of Nd3+-sensitized upconversion nanophosphors for highly efficient UCL imaging and pH-responsive drug delivery. Adv. Funct. Mater. 2015, 25, 4717–4729.CrossRefGoogle Scholar
- Wang, Y. H.; Song, S. Y.; Liu, J. H.; Liu, D. P.; Zhang, H. J. ZnO-functionalized upconvertingnanotheranostic agent: Multi-modality imaging-guided chemotherapy with on-demand drug release triggered by pH. Angew. Chem., Int. Ed. 2015, 54, 536–540.Google Scholar