Nano Research

, Volume 9, Issue 8, pp 2520–2530 | Cite as

Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers

  • Ren Cai
  • Dan Yang
  • Jin Wu
  • Liqin Zhang
  • Cuichen Wu
  • Xigao Chen
  • Yanyue Wang
  • Shuo Wan
  • Fengwei Hou
  • Qingyu Yan
  • Weihong TanEmail author
Research Article


Ultrathin two-dimensional (2D) porous Zn(OH)2 nanosheets (PNs) were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4–10 nm. To form “smart” porous nanosheets, DNA aptamers were covalently conjugated to the surface of PNs. These ultrathin nanosheets show good biocompatibility, efficient cellular uptake, and promising pH-stimulated drug release.


aptamer porous Zn(OH)2 nanosheets cancer cell cell-targeted delivery 


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Supplementary material

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Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Ren Cai
    • 1
  • Dan Yang
    • 3
  • Jin Wu
    • 3
  • Liqin Zhang
    • 1
  • Cuichen Wu
    • 1
  • Xigao Chen
    • 1
  • Yanyue Wang
    • 1
  • Shuo Wan
    • 1
  • Fengwei Hou
    • 3
  • Qingyu Yan
    • 3
  • Weihong Tan
    • 1
    • 2
    Email author
  1. 1.Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain InstituteUniversity of FloridaGainesvilleUSA
  2. 2.Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and TheranosticsHunan UniversityChangshaChina
  3. 3.School of Materials Science and EngineeringNanyang Technological UniversitySingaporeSingapore

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