Nano Research

, Volume 9, Issue 8, pp 2203–2225 | Cite as

A biotechnological perspective on the application of iron oxide nanoparticles

  • Farnaz Assa
  • Hoda Jafarizadeh-MalmiriEmail author
  • Hossein Ajamein
  • Navideh Anarjan
  • Hamideh Vaghari
  • Zahra Sayyar
  • Aydin BerenjianEmail author
Review Article


In recent decades, magnetic iron nanoparticles (NPs) have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.


iron oxide nanoparticle superparamagnetic biotechnology surface modification 


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Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Farnaz Assa
    • 1
  • Hoda Jafarizadeh-Malmiri
    • 1
    Email author
  • Hossein Ajamein
    • 2
  • Navideh Anarjan
    • 3
  • Hamideh Vaghari
    • 1
  • Zahra Sayyar
    • 1
  • Aydin Berenjian
    • 4
    Email author
  1. 1.Faculty of Chemical EngineeringSahand University of TechnologyTabrizIran
  2. 2.Department of Chemical Engineering, Ilkhchi BranchIslamic Azad UniversityIlkhchiIran
  3. 3.Department of Chemical Engineering, Tabriz BranchIslamic Azad UniversityTabrizIran
  4. 4.School of Engineering, Faculty of Science and EngineeringUniversity of WaikatoHamiltonNew Zealand

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