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Nano Research

, Volume 8, Issue 7, pp 2373–2379 | Cite as

X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations

  • Slávka Kaščáková
  • Alexandre Giuliani
  • Sara Lacerda
  • Agnès Pallier
  • Pascal Mercère
  • Éva Tóth
  • Matthieu RéfrégiersEmail author
Research Article

Abstract

We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray-triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance.

Keywords

photodynamic therapy liponanoparticles X-ray deep tumour photosensitizer 

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Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Slávka Kaščáková
    • 1
    • 2
  • Alexandre Giuliani
    • 1
    • 3
  • Sara Lacerda
    • 4
  • Agnès Pallier
    • 4
  • Pascal Mercère
    • 1
  • Éva Tóth
    • 4
  • Matthieu Réfrégiers
    • 1
    Email author
  1. 1.Synchrotron SOLEILL’Orme des MerisiersGif-sur-YvetteFrance
  2. 2.UMR-S1193Université Paris-Sud XIVillejuifFrance
  3. 3.UAR1008 Caractérisation et Élaboration des Produits Issus de l’AgricultureINRANantesFrance
  4. 4.Centre de Biophysique MoléculaireCNRSOrléans Cedex 2France

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