Nano Research

, Volume 8, Issue 5, pp 1637–1647

Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform

  • Feng Hu
  • Chunyan Li
  • Yejun Zhang
  • Mao Wang
  • Dongming Wu
  • Qiangbin Wang
Research Article

DOI: 10.1007/s12274-014-0653-2

Cite this article as:
Hu, F., Li, C., Zhang, Y. et al. Nano Res. (2015) 8: 1637. doi:10.1007/s12274-014-0653-2

Abstract

Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform (DOX@PEG-Ag2S) obtained by loading the anti-cancer drug doxorubicin (DOX) into polyethylene glycol-coated silver sulfide quantum dots (PEG-Ag2S QDs) through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability (93 wt.% of DOX to Ag2S QDs), long circulation in blood (t1/2 = 10.3 h), and high passive tumor-targeting efficiency (8.9% ID/gram) in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose (ID) per gram of tissue. After targeting the tumor tissue, DOX from PEG-Ag2S cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window (NIR-II), the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.

Keywords

in vivo imaging Ag2S quantum dots second near-infrared window fluorescence drug delivery tumor therapy 

Supplementary material

12274_2014_653_MOESM1_ESM.pdf (1.8 mb)
Supplementary material, approximately 1.81 MB.

Supplementary material, approximately 1.38 MB.

Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Feng Hu
    • 1
  • Chunyan Li
    • 1
  • Yejun Zhang
    • 1
  • Mao Wang
    • 1
  • Dongming Wu
    • 1
  • Qiangbin Wang
    • 1
  1. 1.Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouChina

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