Table 1 Effect of intervention compared placebo in meta-analysis results
Outcome | Total Effect | P-value | Heterogeneity | Subgroup difference | GLP1RA | SGLT2i | DPP4i | Metformin | TZD |
|---|---|---|---|---|---|---|---|---|---|
Fracture | OR [95% CI] | |||||||||
Overall Fracture | 0.92 [0.84, 1.01] | 0.07 | 0% | 0.68 | 0.84 [0.69, 1.02] | 0.97 [0.84, 1.12] | 0.87 [0.71, 1.06] | 0.96 [0.09,10.73] | 1.33 [0.54, 3.29] |
Vertebral Fracture | 0.81 [0.62, 1.04] | 0.10 | 0% | 0.82 | 0.68 [0.43, 1.10] | 0.86 [0.59, 1.26] | 0.88 [0.52, 1.50] | NA | 0.41 [0.03, 6.66] |
Non-Vertebral Fracture | 0.95 [0.85, 1.06] | 0.34 | 0% | 0.43 | 0.83 [0.67, 1.01] | 1.03 [0.88, 1.21] | 0.95 [0.78, 1.17] | NA | 1.09 [0.36, 3.30] |
Treatment based Hip Fracture | 0.93 [0.80, 1.09] | 0.36 | 0% | 0.94 | 0.89 [0.67, 1.19] | 0.91 [0.71, 1.16] | 1.01 [0.76, 1.34] | NA | 0.87 [0.11, 6.77] |
Vertebral + Hip Fracture | 0.89 [0.78, 1.02] | 0.10 | 0% | 0.80 | 0.82 [0.65, 1.05] | 0.90 [0.73, 1.10] | 0.98 [0.76, 1.25] | NA | 0.67 [0.13, 3.49] |
Multiple Fracture | 0.85 [0.45, 1.62] | 0.85 | 0% | 0.79 | 1.19 [0.36, 3.96] | 0.83 [0.24, 2.85] | 0.70 [0.26, 1.85] | NA | NA |
Anatomy Fracture | OR [95% CI] | |||||||||
Vertebral Column Fracture | 0.78 [0.58, 1.05] | 0.11 | 0% | 0.68 | 0.64 [0.39, 1.05] | 0.82 [0.48, 1.37] | 0.98 [0.57, 1.67] | NA | NA |
Lower Extremity Fracture | 0.96 [0.85, 1.08] | 0.51 | 0% | 0.63 | 0.84 [0.67, 1.06] | 1.00 [0.82, 1.22] | 1.01 [0.80, 1.26] | NA | 1.19 [0.38, 3.74] |
Upper Extremity Fracture | 0.90 [0.77, 1.06] | 0.20 | 0% | 0.81 | 0.83 [0.62, 1.11] | 0.98 [0.77, 1.25] | 0.84 [0.60, 1.19] | NA | 0.71 [0.09, 5.37] |
Pelvic Girdle Fracture | 0.91 [0.71, 1.16] | 0.45 | 0% | 0.92 | 1.01 [0.64, 1.61] | 0.83 [0.56, 1.21] | 0.94 [0.59, 1.50] | NA | 0.87 [0.11, 6.77] |
Cranial and Facial Fracture | 1.01 [0.70, 1.47] | 0.95 | 0% | 0.42 | 0.84 [0.40, 1.75] | 1.52 [0.83, 2.80] | 0.79 [0.43, 1.45] | NA | 0.51 [0.03, 8.18] |
Thoracic Cage Fracture | 0.87 [0.67, 1.13] | 0.28 | 0% | 0.63 | 0.74 [0.45, 1.23] | 1.08 [0.71, 1.63] | 0.78 [0.47, 1.32] | NA | 0.54 [0.06, 4.96] |
BMD | SMD [95% CI] | |||||||||
Femoral neck BMD | 0.02 [-0.07, 0.12] | 0.64 | 0% | 0.87 | NA | 0.03 [-0.09, 0.16] | NA | 0.00 [-0.19, 0.19] | -0.10 [-0.62, 0.43] |
Total hip BMD | -0.12 [-1.09,0.85] | < 0.01 | 98% | < 0.01 | 2.50 [1.81, 3.18] | 0.00 [-0.15, 0.16] | NA | -2.74 [-3.01, -2.47] | -0.35 [-0.77, 0.07] |
Lumber spine BMD | 0.06 [-0.03, 0.16] | 0.21 | 21% | 0.22 | NA | 0.04 [-0.08, 0.15] | NA | 0.00 [-0.19, 0.19] | 0.49 [-0.03, 1.01] |