Skip to main content
Log in

Implications of inflammatory cell death-PANoptosis in health and disease

  • Review
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript


Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body’s balance, defending against pathogens, and eliminating abnormal cells that could lead to diseases like cancer. Although these pathways operate through distinct mechanisms, recent genetic and pharmacological studies have shown that they can interact and influence each other. The concept of “PANoptosis” has emerged, highlighting the interplay between pyroptosis, apoptosis, and necroptosis, especially during cellular responses to infections. This article provides a concise overview of PANoptosis and its molecular mechanisms, exploring its implications in various diseases. The review focuses on the extensive interactions among different RCD pathways, emphasizing the role of PANoptosis in infections, cytokine storms, inflammatory diseases, and cancer. Understanding PANoptosis is crucial for developing novel treatments for conditions involving infections, sterile inflammations, and cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Data availability

This paper is a review paper and does not contain any data.


Download references


This work was supported by new faculty startup funds from Seoul National University (2023-0024 to R.K), and by a grant (RS-2023-00251395) from the National Research Foundation of Korea (NRF). This work was also supported by a NRF grant funded by the Korean government (MSIT) (RS-2024-00355169 to J.H.H), and by Woosuk University (to J.H.H).


Funding was provided by New faculty startup funds from Seoul National University (Grant No. 2023-0024), National Research Foundation of Korea (Grant No. RS-2023-00251395), Woosuk University, National Research Foundation of Korea (Grant No. RS-2024-00355169).

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Rajendra Karki or Joo-Hui Han.

Ethics declarations

Conflict of interest

The authors declared no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bae, H., Jang, Y., Karki, R. et al. Implications of inflammatory cell death-PANoptosis in health and disease. Arch. Pharm. Res. (2024).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: