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Implications of inflammatory cell death-PANoptosis in health and disease

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Abstract

Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body’s balance, defending against pathogens, and eliminating abnormal cells that could lead to diseases like cancer. Although these pathways operate through distinct mechanisms, recent genetic and pharmacological studies have shown that they can interact and influence each other. The concept of “PANoptosis” has emerged, highlighting the interplay between pyroptosis, apoptosis, and necroptosis, especially during cellular responses to infections. This article provides a concise overview of PANoptosis and its molecular mechanisms, exploring its implications in various diseases. The review focuses on the extensive interactions among different RCD pathways, emphasizing the role of PANoptosis in infections, cytokine storms, inflammatory diseases, and cancer. Understanding PANoptosis is crucial for developing novel treatments for conditions involving infections, sterile inflammations, and cancer.

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Acknowledgements

This work was supported by new faculty startup funds from Seoul National University (2023-0024 to R.K), and by a grant (RS-2023-00251395) from the National Research Foundation of Korea (NRF). This work was also supported by a NRF grant funded by the Korean government (MSIT) (RS-2024-00355169 to J.H.H), and by Woosuk University (to J.H.H).

Funding

Funding was provided by New faculty startup funds from Seoul National University (Grant No. 2023-0024), National Research Foundation of Korea (Grant No. RS-2023-00251395), Woosuk University, National Research Foundation of Korea (Grant No. RS-2024-00355169).

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Correspondence to Rajendra Karki or Joo-Hui Han.

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Bae, H., Jang, Y., Karki, R. et al. Implications of inflammatory cell death-PANoptosis in health and disease. Arch. Pharm. Res. (2024). https://doi.org/10.1007/s12272-024-01506-0

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