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Mediators of the homeostasis and effector functions of memory Th2 cells as novel drug targets in intractable chronic allergic diseases

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Abstract

Allergic patients have life-long chronic inflammatory diseases with repeated relapses and exacerbations. Currently used allergy therapeutics have some limitations, which warrants a search for novel drug targets for allergy treatment. The studies on conventional allergic disease therapeutics have been focused on the pathology of allergy involving effector type 2 helper T cells (Th2). However, it has been suggested that allergen-specific memory Th2 cells are developed after the initial allergen exposure, which may play a critical role in the allergic relapses. Here, we discuss the contribution of memory Th2 cells to allergic diseases and the microenvironmental factors for chronic allergic disease persistence. Since most allergy drugs are prescribed to suppress symptoms of the diseases, targeting the different types of cells or factors contributing to allergic diseases persistence may cure the disease.

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Acknowledgements

This work was supported by the Basic Science Research Program (Grant NRF-2017R1A2B4003376) of the National Research Foundation of Korea funded by the Korea government. We appreciate Kyong Hoon Kim, Hyun Gyung Kim, Sang Hoon Kim, and Ji Hye Moon for their critical comments.

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  1. Department of Pharmacy, Korea University, Sejong-si, Korea

    Seung-min Yeon, Aryeong Choi, Min Soo Hong & Yong Woo Jung

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  1. Seung-min Yeon
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  2. Aryeong Choi
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Correspondence to Yong Woo Jung.

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The Korea University Institutional Animal Care and Use Committees approved all animal protocols (http://kuirb.korea.ac.kr/animalAction/main.do). We carried out all experiments in accordance with the approved guidelines.

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Yeon, Sm., Choi, A., Hong, M.S. et al. Mediators of the homeostasis and effector functions of memory Th2 cells as novel drug targets in intractable chronic allergic diseases. Arch. Pharm. Res. 42, 754–765 (2019). https://doi.org/10.1007/s12272-019-01159-4

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