Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy

Abstract

Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses.

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Acknowledgements

This work was supported by Grants from the National Research Foundation (NRF- 2014R1A5A2009242 and NRF-2018R1A2B200837) and the Bio & Medical Technology Development Program (2017M3A9G8083382).

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Vadevoo, S.M.P., Gurung, S., Khan, F. et al. Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy. Arch. Pharm. Res. 42, 150–158 (2019). https://doi.org/10.1007/s12272-019-01125-0

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Keywords

  • Apoptosis
  • CD44v6
  • Imaging
  • PD-L1
  • Phage display
  • Pro-apoptotic peptide
  • Targeted therapeutics