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Proinvasive extracellular matrix remodeling for tumor progression

Archives of Pharmacal Research volume 42, pages 40–47 (2019)Cite this article

Abstract

Cancer is a systemic disease in which neoplastic cells interact with multiple types of non-neoplastic stromal cells as well as non-cellular components. The extracellular matrix (ECM) is a non-cellular component that is aberrantly regulated in many types of tumor microenvironments. Since the ECM generally maintains the tissue structure and provides mechanical forces in the tumor microenvironment, it has been simply assumed to act as a physical barrier for cancer metastasis and have a passive role in cancer progression. However, a substantial body of evidence has suggested that ECM remodeling influences many aspects of cancer cell behaviors and its importance has attracted attention in cancer biology. Abnormal ECM affects cancer progression through several ways such as inducing hypoxia, immune cells interaction by promoting mesenchymal shift and cell transformation. Accordingly, in this review we summarize and discusses the role of the ECM in modulating epithelial cells and surrounding stomatal cell components and considers its prospects in cancer biology.

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Acknowledgements

This work was supported by the National Research Foundation (NRF) and Ministry of Science, ICT and Future Planning, Korean government, through its National Nuclear Technology Program (2016R1E1A1A01942075).

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Authors and Affiliations

  1. Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea

    Neha Kaushik, Seungmo Kim, Yongjoon Suh & Su-Jae Lee

  2. Department of Life Science, Laboratory of Molecular Biochemistry, Hanyang University, 17 Haengdang-Dong, Seongdong-Ku, Seoul, 04763, Republic of Korea

    Su-Jae Lee

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  1. Neha Kaushik
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  2. Seungmo Kim
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Correspondence to Su-Jae Lee.

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Kaushik, N., Kim, S., Suh, Y. et al. Proinvasive extracellular matrix remodeling for tumor progression. Arch. Pharm. Res. 42, 40–47 (2019). https://doi.org/10.1007/s12272-018-1097-0

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  • DOI: https://doi.org/10.1007/s12272-018-1097-0

Keywords

  • Extracellular matrix
  • Metastatic cancer
  • Cancer stem cells
  • Hypoxia
  • Immune cells