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New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines

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Abstract

Three new limonoids, limonophyllines A-C (1, 4 and 5), along with two known limonoids (2 and 3) and 11 acridone alkaloids (6-16) were isolated from the stems of Atalantia monophylla. All isolates were evaluated against cholangiocarcinoma, KKU-M156, and HepG2 cancer cell lines. Compounds 12, 14 and 16 displayed cytotoxicity against KKU-M156 cell line with IC50 ranging from 3.39 to 4.1 μg/mL while cytotoxicity against HepG2 cell line with IC50 ranging from 1.43 to 8.4 μg/mL. The structures of all isolated compounds were established by spectroscopic methods including 1D and 2D NMR, IR and mass spectrometry.

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Acknowledgements

We thank the Science Achievement Scholarship of Thailand (SAST) for the support to A. Sombatsri. We acknowledge the Thai Research Fund (RSA5980022) and Khon Kaen University for financial support. The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education is gratefully acknowledged.

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Authors and Affiliations

  1. Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

    Aonnicha Sombatsri, Yutthapong Thummanant, Thurdpong Sribuhom & Chavi Yenjai

  2. Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

    Jaursup Boonmak & Sujittra Youngme

  3. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Suphanthip Phusrisom & Veerapol Kukongviriyapan

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  1. Aonnicha Sombatsri
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  2. Yutthapong Thummanant
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  3. Thurdpong Sribuhom
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  4. Jaursup Boonmak
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  7. Veerapol Kukongviriyapan
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  8. Chavi Yenjai
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Correspondence to Chavi Yenjai.

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Dedication

In remembrance of His Majesty King Bhumibol Adulyadej (1927–2016).

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Sombatsri, A., Thummanant, Y., Sribuhom, T. et al. New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines. Arch. Pharm. Res. 41, 431–437 (2018). https://doi.org/10.1007/s12272-018-1021-7

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  • DOI: https://doi.org/10.1007/s12272-018-1021-7

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