Antipsychotic dopamine receptor antagonists, cancer, and cancer stem cells

Abstract

Cancer is one of the deadliest diseases in the world. Despite extensive studies, treating metastatic cancers remains challenging. Years of research have linked a rare set of cells known as cancer stem cells (CSCs) to drug resistance, leading to the suggestion that eradication of CSCs might be an effective therapeutic strategy. However, few drug candidates are active against CSCs. New drug discovery is often a lengthy process. Drug screening has been advantageous in identifying drug candidates. Current understanding of cancer biology has revealed various clues to target cancer from different points of view. Many studies have found dopamine receptors (DRs) in various cancers. Therefore, DR antagonists have attracted a lot of attention in cancer research. Recently, a group of antipsychotic DR antagonists has been demonstrated to possess remarkable abilities to restrain and sensitize CSCs to existing chemotherapeutics by a process called differentiation approach. In this review, we will describe current aspects of CSC-targeting therapeutics, antipsychotic DR antagonists, and their extraordinary abilities to fight cancer.

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Acknowledgements

This research was supported by Grants (NRF-2014R1A1A2059237 and NRF-2016R1D1A1B03936072) of the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Education, Republic of Korea.

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Roney, M.S.I., Park, S. Antipsychotic dopamine receptor antagonists, cancer, and cancer stem cells. Arch. Pharm. Res. 41, 384–408 (2018). https://doi.org/10.1007/s12272-018-1017-3

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Keywords

  • Cancer
  • Cancer stem cells
  • Antipsychotics
  • Dopamine
  • Dopamine receptor antagonist
  • Differentiation therapy