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Archives of Pharmacal Research

, Volume 39, Issue 6, pp 778–784 | Cite as

Endoperoxy and hydroperoxy cadinane-type sesquiterpenoids from an Okinawan soft coral, Sinularia sp.

  • Prodip K. RoyEmail author
  • Runa Ashimine
  • Haruna Miyazato
  • Junsei Taira
  • Katsuhiro UedaEmail author
Research Article

Abstract

Three cadinane-type sesquiterpenoids, endoperoxide (1) and hydroperoxides (2, 3) together with three known sesquiterpenoids (46) were isolated from an Okinawan soft coral, Sinularia species. Structures of these isolates were elucidated by spectroscopic analyses (NMR, IR and MS) and molecular modeling. In addition, the isolates 13 as new compounds were examined for biological activities, resulting that they have antibacterial activity and weak cytotoxicity against HCT116 cells as well as anti-inflammatory effect on LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.

Keywords

Cytotoxicity Cadinane Sesquiterpenoid HCT 116 cells Anti-inflammatory Sinularia 

Notes

Acknowledgments

We are grateful to the Japanese Government (Ministry of Education, Culture, Sports, Science, and Technology) for funding of the research. The authors thank the IRC, at the University of the Ryukyus for analytical services. The authors are also thankful to Dr. Michael C. Roy (OIST) for recording accurate mass spectra and Prof. M. Tofazzal Islam (Bangabandhu Sheikh Mujibur Rahman Agriculture University) for editing the manuscript.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interests.

Supplementary material

12272_2016_759_MOESM1_ESM.docx (1.7 mb)
Supplementary material 1 (DOCX 1768 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2016

Authors and Affiliations

  1. 1.Department of Chemistry, Biology, and Marine ScienceUniversity of the RyukyusNishihara-ChoJapan
  2. 2.Department of Bioresources EngineeringOkinawa National College of TechnologyNago-ShiJapan

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