Endoperoxy and hydroperoxy cadinane-type sesquiterpenoids from an Okinawan soft coral, Sinularia sp.
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Three cadinane-type sesquiterpenoids, endoperoxide (1) and hydroperoxides (2, 3) together with three known sesquiterpenoids (4–6) were isolated from an Okinawan soft coral, Sinularia species. Structures of these isolates were elucidated by spectroscopic analyses (NMR, IR and MS) and molecular modeling. In addition, the isolates 1–3 as new compounds were examined for biological activities, resulting that they have antibacterial activity and weak cytotoxicity against HCT116 cells as well as anti-inflammatory effect on LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
KeywordsCytotoxicity Cadinane Sesquiterpenoid HCT 116 cells Anti-inflammatory Sinularia
We are grateful to the Japanese Government (Ministry of Education, Culture, Sports, Science, and Technology) for funding of the research. The authors thank the IRC, at the University of the Ryukyus for analytical services. The authors are also thankful to Dr. Michael C. Roy (OIST) for recording accurate mass spectra and Prof. M. Tofazzal Islam (Bangabandhu Sheikh Mujibur Rahman Agriculture University) for editing the manuscript.
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Conflict of interest
All authors declare that they have no conflict of interests.
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