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Archives of Pharmacal Research

, Volume 39, Issue 3, pp 421–428 | Cite as

Antiinflammatory and analgesic effects of Eurycoma longifolia extracts

  • Young Min Han
  • Sang-Uk Woo
  • Min Sun Choi
  • Yu Na Park
  • Seung Hyun Kim
  • Hyungshin YimEmail author
  • Hye Hyun YooEmail author
Research Article

Abstract

Eurycoma longifolia is one of the most popular herbal medicines in Southeast Asia. The purpose of this study is to evaluate the analgesic and anti-inflammatory effects of the methanolic extract of E. longifolia roots (TA) in vivo and to investigate the underlying mechanisms. TA was tested for analgesic activity by the hot plate test and acetic acid test in mice. The anti-inflammatory effect of TA was observed in carrageenan-induced paw edema in mice. The in vitro molecular study using macrophage cells was performed to elucidate the relevant mechanism. The analgesic activity of 400 mg/kg TA was higher than that of aspirin in the hot plate test. TA also showed analgesic effects in the acetic acid test in a dose-dependent manner. In carrageenan-induced edema in mice, TA showed an anti-inflammatory effect comparable to that of diclofenac. Further in vitro molecular study using macrophage cells revealed that TA suppressed NF-κB translocation to the nucleus, leading to inactivation of the NF-κB signaling pathway and reduction in the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These results exhibited the beneficial effects of TA for alleviating pain and inflammation, which were exerted through inactivation of the NF-κB signaling pathway.

Keywords

Eurycoma longifolia Simaroubaceae Analgesics Anti-inflammation 

Notes

Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2014R1A1A1A05002840 and NRF-2014R1A2A1A11049701).

Compliance with ethical standard

Conflict of interest

No competing financial interests exist.

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Copyright information

© The Pharmaceutical Society of Korea 2016

Authors and Affiliations

  • Young Min Han
    • 1
  • Sang-Uk Woo
    • 1
  • Min Sun Choi
    • 1
  • Yu Na Park
    • 1
  • Seung Hyun Kim
    • 2
  • Hyungshin Yim
    • 1
    Email author
  • Hye Hyun Yoo
    • 1
    Email author
  1. 1.Institute of Pharmaceutical Science and Technology and College of PharmacyHanyang UniversityAnsanRepublic of Korea
  2. 2.College of Pharmacy, Yonsei Institute of Pharmaceutical SciencesYonsei UniversityIncheonRepublic of Korea

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