A mycoparasite PG52 isolated from aeciospore piles of Aecidium pourthiaea was identified as Pestalotipsis sp. The chemical constituents of Pestalotipsis sp. PG52 were investigated. Four novel polyketides, named pestalpolyols E–H (1–4), were isolated from solid fermentations of Pestalotiopsis sp. PG52. Their structures were elucidated by interpretation of extensive spectroscopic methods, including 1D and 2D NMR, HR-MS experiments; and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis using the anomalous scattering of Cu Kα radiation. Compounds 2–4 showed cytotoxic activities against human tumor cell lines.
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This work was supported by the National Basic Research Program of China (973 Program, 2013CB127505), the NSFC (31170061) and the Applied Basic Research Foundation of Yunnan Province (2013FA018). We acknowledge the Department of Instrumental Analysis of Kunming Institute of Botany for measuring the optical rotations, UV, NMR, X-ray and mass spectra.
Conflict of interest
The authors have no conflict of interest to declare.
Jin Xie and Jing Li have contributed equally to this work.
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Xie, J., Li, J., Yang, YH. et al. Four pestalpolyols from a mycoparasite Pestalotipsis sp. PG52. Arch. Pharm. Res. (2015). https://doi.org/10.1007/s12272-015-0675-7
- Pestalotiopsis sp. PG52
- Cytotoxic activity