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Archives of Pharmacal Research

, Volume 40, Issue 11, pp 1265–1270 | Cite as

New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity

  • Jia-Lin Li
  • Na Li
  • Shan-Shan Xing
  • Nan Zhang
  • Ban-Ban Li
  • Jian-Guang Chen
  • Jong-Seog Ahn
  • Long Cui
Research Article

Abstract

New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (28) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50 value 15.2 ± 1.4 µM.

Keywords

Acanthopanax senticosus Araliaceae PTP1B Neo-lignan 

Notes

Acknowledgments

This research was financially supported by the Project Sponsored by the Scientific and Technological Developing Scheme of Jilin Province of People’s Republic of China (YYZX201240 and 20150101225JC) and Jilin Shizandra Development & Industrialization Engineering Research Center (2013G020).

Compliance with ethical standards

Conflict of interest

Authors declare that there is no conflict of interest.

Supplementary material

12272_2015_659_MOESM1_ESM.doc (418 kb)
Supplementary material 1 (DOC 419 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2015

Authors and Affiliations

  • Jia-Lin Li
    • 1
  • Na Li
    • 1
  • Shan-Shan Xing
    • 1
  • Nan Zhang
    • 2
  • Ban-Ban Li
    • 1
  • Jian-Guang Chen
    • 1
  • Jong-Seog Ahn
    • 3
  • Long Cui
    • 1
  1. 1.College of PharmacyBeihua UniversityJilin CityPeople’s Republic of China
  2. 2.The Second Affiliated Hospital of Shenyang Medical CollegeShenyangPeople’s Republic of China
  3. 3.Chemical Biology Research CenterKorea Research Institute of Bioscience and Biotechnology (KRIBB)ChungbukRepublic of Korea

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