New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity
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New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2–8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50 value 15.2 ± 1.4 µM.
KeywordsAcanthopanax senticosus Araliaceae PTP1B Neo-lignan
This research was financially supported by the Project Sponsored by the Scientific and Technological Developing Scheme of Jilin Province of People’s Republic of China (YYZX201240 and 20150101225JC) and Jilin Shizandra Development & Industrialization Engineering Research Center (2013G020).
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Conflict of interest
Authors declare that there is no conflict of interest.
- Hashimoto, Y., S. Ozawa, and T. Sasaya. 1994. New neolignans from the wood of Chosenia arbutifolia. Mokuzai Gakkaishi 40: 549–553.Google Scholar
- Xie, L.H., T. Akao, K. Hamasaki, T. Deyama, and M. Hattori. 2003. Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of Enterococcus faecalis Strain PDG-1 responsible for the transformation of (1)-pinoresinol to (1)-lariciresinol. Chemical & Pharmaceutical Bulletin 51: 508–515.CrossRefGoogle Scholar
- Yook, C.S., S.C. Kim, C.J. Kim, and D.R. Han. 1991. Phytochemical studies on the barks of Acanthopanax senticosus forma inermis. Yakhak Hoeji 35: 147–153.Google Scholar