Archives of Pharmacal Research

, Volume 38, Issue 9, pp 1617–1626 | Cite as

Existing drugs and their application in drug discovery targeting cancer stem cells

Review

Abstract

Despite standard cancer therapies such as chemotherapy and targeted therapy have shown some efficacies, the cancer in many cases eventually relapses and metastasizes upon stopping the treatment. There is a small subpopulation of cancer cells within tumor, with specific characters similar to those found in stem cells. This group of cancer cells is known as tumor-initiating or cancer stem cells (CSCs), which have an ability to self-renew and give rise to cancer cell progeny. CSCs are related with drug resistance, metastasis and relapse of cancer, hence emerging as a crucial drug target for eliminating cancer. Rapid advancement of CSC biology has enabled researchers to isolate and culture CSCs in vitro, making the cells amenable to high-throughput drug screening. Recently, drug repositioning, which utilizes existing drugs to develop potential new indications, has been gaining popularity as an alternative approach for the drug discovery. As existing drugs have favorable bioavailability and safety profiles, drug repositioning is now actively exploited for prompt development of therapeutics for many serious diseases, such as cancer. In this review, we will introduce latest examples of attempted drug repositioning targeting CSCs and discuss potential use of the repositioned drugs for cancer therapy.

Keywords

Cancer stem cell Drug repositioning Niclosamide Metformin Choloroquine 

Notes

Acknowledgments

This work was supported by the Science and Technology Development Fund (FDCT) of Macau SAR (FDCT/119/2013/A3), Matching Research Grant (MRG002/JSS/2015/FHS) and Multi-Year Research Grant (MYRG2015-00181-FHS) of the University of Macau.

Compliance with Ethical Standards

Conflict of interest

The authors have declared that there are no conflict of interest.

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Copyright information

© The Pharmaceutical Society of Korea 2015

Authors and Affiliations

  1. 1.Faculty of Health SciencesUniversity of MacauMacau, SARChina

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