Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXRα. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.
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This research was supported by Industrialization Support Program for Bio-technology of Agriculture and Forestry, Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea. And this research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2012R1A3A2026454).
Conflict of interest
The Authors have declared that there is no conflict of interest to disclose.
Se-Jin Jeong and Jong-Gil Park have contributed equally to this work.
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Jeong, SJ., Park, JG., Kim, S. et al. Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice. Arch. Pharm. Res. 38, 2049–2058 (2015). https://doi.org/10.1007/s12272-015-0579-6
- Rhus verniciflua stokes (RVS)
- Bile acid biosynthesis
- Liver X receptor α (LXRα)