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Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice

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Abstract

Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXRα. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.

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Acknowledgments

This research was supported by Industrialization Support Program for Bio-technology of Agriculture and Forestry, Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea. And this research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2012R1A3A2026454).

Conflict of interest

The Authors have declared that there is no conflict of interest to disclose.

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    Authors and Affiliations

    1. Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences and GT5 Program, Ewha Womans University, Seoul, Republic of Korea

      Se-Jin Jeong, Sinai Kim, Hyae Yon Kweon, Seungwoon Seo & Goo Taeg Oh

    2. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA

      Jong-Gil Park

    3. College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea

      Dongho Lee

    4. Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd, Gyeonggi-Do, Republic of Korea

      Cheol Yi Hong & Chun-Soo Na

    5. School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea

      Dae-Seung Na & Mi-Sook Dong

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    Correspondence to Goo Taeg Oh.

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    Se-Jin Jeong and Jong-Gil Park have contributed equally to this work.

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    Jeong, SJ., Park, JG., Kim, S. et al. Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice. Arch. Pharm. Res. 38, 2049–2058 (2015). https://doi.org/10.1007/s12272-015-0579-6

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