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Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet

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Abstract

Orally disintegrating tablet (ODT) is a user friendly and convenient dosage form. The study aimed to investigate the effect of polymers and wheat starch on the tablet properties of lyophilized ODT, with dapoxetine as model drug. Three polymers (hydroxypropylmethyl cellulose, carbopol 934P and Eudragit® EPO) and wheat starch were used as matrix forming materials in preparation of lyophilized ODT. The polymeric dispersion was casted into a mould and kept in a freezer at −20 °C for 4 h before freeze dried for 12 h. It was found that increasing in HPMC and Carbopol 934P concentrations produced tablets with higher hardness and longer disintegration time. In contrast, Eudragit® EPO was unable to form tablet with sufficient hardness at various concentrations. Moreover, HPMC seems to have a stronger effect on tablet hardness compared to Carbopol 934P at the same concentration level. ODT of less friable was obtained. Wheat starch acted as binder which strengthen the hardness of ODTs and prolonged the disintegration time. ODT comprising of HPMC and wheat starch at ratio of 2:1 was found to be optimum based upon the tablet properties. The optimum formulation was palatable and 80 % of the drug was released within 30 min in the dissolution study.

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Acknowledgments

The authors thank University Sains Malaysia for providing the laboratory instruments and facilities for the successful conduct of the research. The authors would like to express deepest gratitude to Kementerian Pengajian Tinggi Malaysia (Higher Education Ministry) for providing the scholarship under MyBrain 15 programme.

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The authors report no conflict of interest.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia

    Kai Bin Liew & Kok Khiang Peh

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  1. Kai Bin Liew
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  2. Kok Khiang Peh
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Correspondence to Kok Khiang Peh.

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Liew, K.B., Peh, K.K. Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet. Arch. Pharm. Res. 44, 1–10 (2021). https://doi.org/10.1007/s12272-014-0542-y

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  • DOI: https://doi.org/10.1007/s12272-014-0542-y

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