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Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

Archives of Pharmacal Research volume 38, pages 1443–1448 (2015)Cite this article

Abstract

One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (−)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 µM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 µM.

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Acknowledgments

This research was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2011.23 and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2011-0025129).

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Affiliations

  1. College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 406-840, Korea

    Nguyen Xuan Nhiem, SeonJu Park, Nanyoung Kim & Seung Hyun Kim

  2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

    Chau Van Minh, Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Kiem, Bui Huu Tai & Hoang Le Tuan Anh

  3. Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam

    Truong Thi Thu Hien

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  1. Chau Van Minh
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  2. Nguyen Xuan Nhiem
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  3. Hoang Thi Yen
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  4. Phan Van Kiem
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  5. Bui Huu Tai
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  6. Hoang Le Tuan Anh
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  7. Truong Thi Thu Hien
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  8. SeonJu Park
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  9. Nanyoung Kim
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  10. Seung Hyun Kim
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Correspondence to Seung Hyun Kim.

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Minh, C.V., Nhiem, N.X., Yen, H.T. et al. Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Arch. Pharm. Res. 38, 1443–1448 (2015). https://doi.org/10.1007/s12272-014-0490-6

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  • DOI: https://doi.org/10.1007/s12272-014-0490-6

Keywords

  • Trichosanthes kirilowii
  • Cucurbitaceae
  • Trichobenzolignan
  • Cytotoxic activity