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Two new sesquiterpenoids from endophytic fungus J3 isolated from Mangrove Plant Ceriops tagal

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Abstract

Two new sesquiterpenoids, named 2α-hydroxyxylaranol B (1) and 4β-hydroxyxylaranol B (2), together with a known diterpenoid 3,4-seco-sonderianol (3) were isolated from the fermentation of endophytic fungus J3 of Ceriops tagal. Their structures were elucidated based on spectroscopic methods including 1D and 2D NMR (HMQC, 1H-1H COSY and HMBC). All compounds were evaluated for their cytotoxic activities by MTT method, and compound 3 exhibited cytotoxic activities against K562, SGC-7901, and BEL-7402 cell lines.

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Acknowledgments

This research was financially supported by the Program for the Top Young Talents in CATAS (ITBB140402), Innovation Introduction of Integrated Special Science and Technology Cooperation Project (GJHZ2013-17), National Non-profit Institute Research Grant of CATAS-ITBB (ITBB130405) and Natural Science Foundation of Hainan Province (No. 313079). Authors (Dr. Y.-B. Zeng and Prof. H.-F. Dai) wish to thank the KCWEF and DAAD for scholarships.

Conflict of interest

All the authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China

    Yan-Bo Zeng, Hai-Gang Gu, Wen-Jian Zuo, Zhi-Kai Guo, Wen-Li Mei & Hao-Fu Dai

  2. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University Duesseldorf, 40225, Duesseldorf, Germany

    Yan-Bo Zeng & Peter Proksch

  3. College of Life Science, Tarim University, Alar, 843300, China

    Li-Li Zhang & Hong-Jin Bai

  4. Center for Disease Control and Prevention, Xinhe, 842100, China

    Hai-Gang Gu

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  1. Yan-Bo Zeng
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  2. Hai-Gang Gu
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  3. Wen-Jian Zuo
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  8. Wen-Li Mei
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  9. Hao-Fu Dai
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Corresponding authors

Correspondence to Wen-Li Mei or Hao-Fu Dai.

Additional information

Yan-Bo Zeng and Hai-Gang Gu were contributed equally to this work.

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Zeng, YB., Gu, HG., Zuo, WJ. et al. Two new sesquiterpenoids from endophytic fungus J3 isolated from Mangrove Plant Ceriops tagal . Arch. Pharm. Res. 38, 673–676 (2015). https://doi.org/10.1007/s12272-014-0448-8

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  • DOI: https://doi.org/10.1007/s12272-014-0448-8

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