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Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats

Archives of Pharmacal Research volume 39, pages 221–230 (2016)Cite this article

Abstract

Gynostemma pentaphyllum (GP) is a natural plant resources for diabetes therapy, however, there is little research on the mechanisms of GP. The present study was undertaken to characterize if G. pentaphyllum saponins (GPs) is the principal active compound of GP responsible for anti-diabetes, and to examine the relativity between blood glucose modulate and antioxidation. The GPs-treated streptozotocin diabetic rats had a more effective hypoglycemic status than those of diabetic control rats, which also ameliorate dyslipidemia. GPs has increased SOD and GSH-px activities, and the spleen and thymus indexes in diabetic rats. The insulin levels in the GPs-treated groups were significantly higher than diabetic control group. Our finding provides a new insight into the application of GPs for the treatment of oxidative stress related diseases.

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Acknowledgments

This work was supported by Hebei Province Natural Science Fund (No. C2011203137, 11965152D) and Foundation of Ministry of Education Doctor Degree (No. 20101333120011).

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Authors and Affiliations

  1. Applied Chemical Key Lab of Hebei Province, Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China

    Dawei Gao, Yanping Liu, Nan Li, Zhiwei Liu & Yanhong Bian

  2. Department of Pathology, The First Hospital of Qinhuangdao, No. 258 Cultural Road, Qinhuangdao, 066004, China

    Min Zhao & Ximing Qi

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  1. Dawei Gao
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  2. Min Zhao
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Correspondence to Dawei Gao.

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Gao, D., Zhao, M., Qi, X. et al. Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats. Arch. Pharm. Res. 39, 221–230 (2016). https://doi.org/10.1007/s12272-014-0441-2

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Keywords

  • Gynostemma pentaphyllum saponins
  • Hypoglycemia
  • Nuclear factor erythroid 2-related factor 2 (Nrf2)
  • Insulin
  • Reactive oxygen species