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Cytotoxic triterpenoids from Saussurea phyllocephala

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Abstract

Three new triterpenoids, 11α-hydroxy-lup-20(29)-ene-3β-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3β-palmitate (2), and 1β,11α,28-tyrihydroxy oleana-9(11),12-dien-3β-palmitate (3), together with three known compounds were isolated from the 95 % EtOH extract of Saussurea phyllocephala. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. All the triterpenoids were in vitro evaluated for their cytotoxic activities. Compound 1–3 exhibited the significant cytotoxic activities with low IC50 values (IC50 < 4.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).

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Acknowledgments

The above research was made possible by the grant from the Scientific Planning Project of the Applied Basic Research of Yunnan Province (S2012FZ0005), the Key Projects of Scientific Research Foundation of the Department of Education of Yunnan Province (2013Z095), and the Developing Key Subject of Ecology of Qujing Normal University.

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Authors and Affiliations

  1. College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan Province, China

    Jiang Hu, Xiao Mao & Xiaodong Shi

  2. Institute of Characteristic Medicinal Resource of Ethnic Minorities, Qujing Normal University, Qujing, 655011, China

    Jiang Hu

  3. Department of Pharmacy, 455 Hospital of People’s Liberation Army, Shanghai, 200052, China

    Yan Song & Xiang Zuo

  4. Institute of Microbiology, Qujing Medical College, Qujing, 655000, Yunnan Province, China

    Benshou Yang

Authors
  1. Jiang Hu
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  2. Yan Song
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  3. Benshou Yang
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  4. Xiang Zuo
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  5. Xiao Mao
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  6. Xiaodong Shi
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Corresponding authors

Correspondence to Jiang Hu or Xiaodong Shi.

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Jiang Hu and Yan Song have contributed equally to this work.

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Hu, J., Song, Y., Yang, B. et al. Cytotoxic triterpenoids from Saussurea phyllocephala . Arch. Pharm. Res. 37, 1515–1521 (2014). https://doi.org/10.1007/s12272-014-0428-z

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  • DOI: https://doi.org/10.1007/s12272-014-0428-z

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