Archives of Pharmacal Research

, Volume 38, Issue 4, pp 480–484 | Cite as

Chemical constituents from the leaves of Juglans mandshurica

  • Da Lei Yao
  • Chang Hao Zhang
  • Jie Luo
  • Mei Jin
  • Ming Shan Zheng
  • Jiong Mo Cui
  • Jong Keun Son
  • Gao LiEmail author
Research Article


Two new (1 and 3) and two known diarylheptanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four phenylpropanoids (811), and one phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively.


Juglans mandshurica Juglandaceae Diarylheptanoid Cytotoxicity Tetralone Phenylpropanoid 



This work was supported by the National Natural Science Foundation of China under Grant Numbers 30760291, 81160386, and 30911140276.

Supplementary material

12272_2014_398_MOESM1_ESM.doc (1.3 mb)
Supplementary material 1 (DOC 1370 kb)


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Copyright information

© The Pharmaceutical Society of Korea 2014

Authors and Affiliations

  • Da Lei Yao
    • 1
  • Chang Hao Zhang
    • 1
  • Jie Luo
    • 1
  • Mei Jin
    • 1
    • 2
  • Ming Shan Zheng
    • 1
  • Jiong Mo Cui
    • 1
  • Jong Keun Son
    • 3
  • Gao Li
    • 1
    Email author
  1. 1.Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of EducationYanbian University College of PharmacyYanjiPeople’s Republic of China
  2. 2.Yanbian University HospitalYanjiChina
  3. 3.College of PharmacyYeungnam UniversityGyeongsanKorea

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