Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model

  • Karim RaafatEmail author
  • Maha Aboul-Ela
  • Abdalla El-Lakany
Research Article


Rheum ribes L., known as Syrian rhubarb, is used in traditional Lebanese folk medicine for the treatment of diabetes. The present study aims to investigate the activities of R. ribes aqueous extract for glucose homeostasis, in vivo antioxidant and diabetic neuropathy protection in mice. The acute and the subacute effects of various doses of R. ribes on blood glucose and in vivo antioxidant activity utilizing serum catalase level (CAT) were studied in alloxan-diabetic mice. The high doses significantly lowered glucose level and increased serum CAT in alloxan-diabetic mice. Pretreatment with the extract prior to alloxination, protected the mice from acquiring diabetes and diabetic neuropathy. Treatment with the extract for 8 weeks alleviated hyperalgesia in diabetic mice. Our findings provide clinicians with promising drugs intended for the management of the symptoms of diabetic complications. The protective activity of R. ribes against acquiring diabetes and diabetic neuropathy might pave the way for preparing a prophylactic treatment for diabetes risk groups.


Rheum ribes L. Diabetes Diabetic neuropathy Alloxan Pain In-vivo antioxidant 



Diabetes mellitus


Rutin rich fraction




Reversed phase


Dimethyl sulfoxide


Lethality towards 50 % of a population



R. ribes

Rheum ribes


Reactive oxygen species





Authors would like to thank the Junior Research Team, Department of Pharmaceutical Sciences, Faculty of Pharmacy, BAU for helping in the methodology preparation.

Conflict of interest

The authors declare that there is no conflict of interest.


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Copyright information

© The Pharmaceutical Society of Korea 2014

Authors and Affiliations

  • Karim Raafat
    • 1
    Email author
  • Maha Aboul-Ela
    • 1
  • Abdalla El-Lakany
    • 1
  1. 1.Department of Pharmaceutical Sciences, Faculty of PharmacyBeirut Arab University (BAU)BeirutLebanon

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