Carbon-based drug delivery carriers for cancer therapy
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In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug solubility, an ability to reduce systemic toxicity through specific-tumor targeting, and rapid clearance. In this regard, carbon allotropes such as graphene oxide (GOs), carbon nanotubes (CNTs), and nanodiamonds (NDs), have been investigated, as they possess sufficient surface-to-volume ratio, thermal conductivity, rigid structural properties capable of post-chemical modification, and excellent biocompatibility. This review is aimed at exploring these carbon-based nanomaterials for use as multifaceted cancer drug carriers and is intended to demonstrate that GOs, CNTs, and NDs are likely to improve chemotherapeutical strategy for cancers in either a sole or combinational manner.
KeywordsNanodiamonds Graphene oxide Carbon nanotube Drug delivery
- Bhirde, A.A., V. Patel, J. Gavard, G. Zhang, A.A. Sousa, A. Masedunskas, R.D. Leapman, R. Weigert, J.S. Gutkind, and J.F. Rusling. 2009. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 3: 307–316.PubMedCentralPubMedCrossRefGoogle Scholar
- Heister, E., V. Neves, C. Tîlmaciu, K. Lipert, V.S. Beltrán, H.M. Coley, S.R.P. Silva, and J. Mcfadden. 2009. Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy. Carbon 47: 2152–2160.CrossRefGoogle Scholar
- Markovic, Z.M., L.M. Harhaji-Trajkovic, B.M. Todorovic-Markovic, D.P. Kepic, K.M. Arsikin, S.P. Jovanovic, A.C. Pantovic, M.D. Dramicanin, and V.S. Trajkovic. 2011. In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes. Biomaterials 32: 1121–1129.PubMedCrossRefGoogle Scholar
- Zhu, S., J. Li, Y. Chen, Z. Chen, C. Chen, Y. Li, Z. Cui, and D. Zhang. 2012. Grafting of graphene oxide with stimuli-responsive polymers by using ATRP for drug release. Journal of Nanoparticle Research 14: 1–11.Google Scholar