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Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65

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Abstract

Two new meroterpenoids, arisugacins I (1) and J (2), together with five known meroterpenoids including arisugacin B (3), arisugacin F (4), arisugacin G (5), territrem B (6) and territrem C (7) were isolated from an endophytic fungus Penicillium sp. SXH-65. Their structures were determined by extensive spectroscopic experiments and comparison with literature data. Their cytotoxicities were evaluated against Hela, HL-60 and K562 cell lines, and only 3 and 4 exhibited weak cytotoxicities against Hela, HL-60 and K562 cell lines with IC50 values ranging from 24 to 60 μM.

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Acknowledgments

This work was supported by the Chinese National Science Fund (No. 41176120), Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (No. BS2010HZ027), Specialized Research Fund for the Doctoral Program of Higher Education (No. 20100132120026), the Public Projects of State Oceanic Administration (No. 2010418022-3), and the state key laboratory of Bio-organic and Natural Products Chemistry (No. SKLBNPC12331).

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Authors and Affiliations

  1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People’s Republic of China

    Xinhua Sun, Xianglan Kong, Huquan Gao, Tianjiao Zhu, Guangwei Wu, Qianqun Gu & Dehai Li

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  1. Xinhua Sun
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  2. Xianglan Kong
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  3. Huquan Gao
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  4. Tianjiao Zhu
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  5. Guangwei Wu
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  6. Qianqun Gu
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  7. Dehai Li
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Correspondence to Dehai Li.

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Sun, X., Kong, X., Gao, H. et al. Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65. Arch. Pharm. Res. 37, 978–982 (2014). https://doi.org/10.1007/s12272-013-0268-2

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