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(−)-Catechin glycosides from Ulmus davidiana

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Abstract

Extensive chromatographic separation of the n-BuOH soluble fraction obtained from the stem and root barks of U. davidiana resulted in five hitherto unknown compounds together with a known one (−)-catechin 1. Structures of the five compounds were elucidated by chemical and spectroscopic analyses, to be (−)-catechin-7-O-gallate-5-O-(5″″-trans-caffeoyl)-β-d-apiofuranoside-3-O-β-d-apiofuranosyl-(1 → 2)-β-d-glucopyranoside 2, (−)-catechin-7-O-gallate-5-O-(5″″-trans-caffeoyl)-β-d-apiofuranoside-3-O-β-d-glucopyranoside 3, (−)-catechin-7-O-gallate-5-O-β-d-apiofuranoside-3-O-(2″-O-galloyl)-β-d-glucopyranoside 4, (−)-catechin-7-O-gallate-5-O-(5″″-trans-caffeoyl)-β-d-apiofuranoside 5, and (−)-catechin-7-O-gallate-5-O-(5″″-trans-feruloyl)-β-d-apiofuranoside 6.

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Acknowledgments

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (2005-0049417) and a grant (09112KFDA817 and 12172KFDA989) from the National Center for Standardization of Herbal Medicine funded by the Korea Food Drug Administration, Republic of Korea 2010.

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Authors and Affiliations

  1. Medicinal and Natural Products Chemistry and Center of Biocatalysis and Bioprocessing, College of Pharmacy, The University of Iowa, Iowa City, IA, 52242, USA

    Mohammed Hosny

  2. College of Pharmacy, Yanbian University, Yanji, 133000, People’s Republic of China

    Ming-Shan Zheng

  3. College of Pharmacy, Catholic University of Daegu, Gyeongsan, 712-702, Korea

    Mi-Hee Woo

  4. College of Pharmacy, Yeungnam University, Kyongsan, 712-749, Korea

    Haiyan Zhang, Hyun-Wook Chang & Jong-Keun Son

  5. Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, 95817, USA

    Sunny Kyung-Seon Lee

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  1. Mohammed Hosny
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  2. Ming-Shan Zheng
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  3. Haiyan Zhang
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  4. Hyun-Wook Chang
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  5. Mi-Hee Woo
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  6. Jong-Keun Son
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  7. Sunny Kyung-Seon Lee
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Corresponding authors

Correspondence to Jong-Keun Son or Sunny Kyung-Seon Lee.

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Mohammed Hosny and Ming Shan Zheng contributed equally to this work.

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Hosny, M., Zheng, MS., Zhang, H. et al. (−)-Catechin glycosides from Ulmus davidiana . Arch. Pharm. Res. 37, 698–705 (2014). https://doi.org/10.1007/s12272-013-0264-6

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  • DOI: https://doi.org/10.1007/s12272-013-0264-6

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