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Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells

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Abstract

A new series of 3-allylseleno-6-alkylthiopyridazines 6a–6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (No 2012050022). We acknowledge to the professor Joohee Jung (College of Pharmacy, Duksung Women’s University) for the CCK-8 assays of antiproliferative activities.

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  1. College of Pharmacy, Duksung Women’s University, Seoul, 132-714, Korea

    Chaewon Kim, Saet-Byeul Kim & Myung-Sook Park

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  1. Chaewon Kim
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  2. Saet-Byeul Kim
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  3. Myung-Sook Park
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Correspondence to Myung-Sook Park.

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Kim, C., Kim, SB. & Park, MS. Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells. Arch. Pharm. Res. 37, 452–458 (2014). https://doi.org/10.1007/s12272-013-0244-x

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  • DOI: https://doi.org/10.1007/s12272-013-0244-x

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